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It was great fun collaborating with Scott Berry's lab, as always! @scottbscience.bsky.social @cftbla.bsky.social Wonderful to see this work online ๐Ÿงช ๐Ÿ”ฌ ๐Ÿงซ! How cells respond to changes in RNA Pol II abundance ๐Ÿ‘‡
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Ana Tufegdzic Vidakovic
What happens when you suddenly remove half of an essential enzyme from cells? ๐Ÿค” We watched in real-time as cells deploy multiple backup strategies to buffer against changes in RNA Pol II abundance. Our lab's new preprint ๐Ÿ‘‡ bit.ly/4pyPgax
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RNA polymerase II (Pol II) abundance and transcriptional output are coordinated across diverse conditions to maintain mRNA homeostasis. To determine whether Pol II acts as a limiting factor for transc...
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Hierarchical buffering of cellular RNA polymerase II pools maintains transcriptional homeostasis
Scott Berry