Group leader at Single Molecule Science and UNSW RNA Institute at the University of New South Wales, Sydney. Interested in quantitative regulation of gene expression in single cells. Views my own. @scottbscience https://berrygroup.github.io
Scott Berry
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Online Now: Accessory subunits of PRC2 mimic H3K27me3 to restrict the spread of Polycomb domains Online now:
Happy to share a new preprint from our lab, uncovering "spooky action at a distance" - for RNA Polymerase II:
www.biorxiv.org/content/10.6...
Optimised nanobody-based quenchbodies are developed through rational design and in vitro evolution, enabling improved protein detection with up to 2.4-fold fluorescence increase @haiboyu.bsky.social
@lisannes.bsky.social @molecularhorizons.bsky.social
www.nature.com/articles/s42...
🎉 𝙒𝙝𝙖𝙩 𝙖 𝙙𝙖𝙮! 🎉
On Thursday we held our inaugural EMCR Mini Symposium, bringing together six in-person nodes plus online attendees from across Australasia. It was fantastic to see our community come together to share science, build connections, and finish 2025 strong.
#EMCR #AEpiA #epigenetics
🌟 𝐈𝐧𝐭𝐫𝐨𝐝𝐮𝐜𝐢𝐧𝐠 𝐄𝐌𝐂𝐑 𝐌𝐢𝐧𝐢 𝐒𝐲𝐦𝐩𝐨𝐬𝐢𝐮𝐦 𝐂𝐚𝐫𝐞𝐞𝐫 𝐏𝐚𝐧𝐞𝐥𝐥𝐢𝐬𝐭 – 𝐃𝐫 𝐋𝐮𝐤𝐞 𝐈𝐬𝐛𝐞𝐥 🌟
We’re excited to spotlight Dr Luke Isbel, one of our inspiring career development panellists for the upcoming Australasian Epigenetics Alliance 𝐄𝐌𝐂𝐑 𝐌𝐢𝐧𝐢 𝐒𝐲𝐦𝐩𝐨𝐬𝐢𝐮𝐦!
aepia.org.au/emcr-symposium
AEpiA 2026 early bird registration open now!
Calling all epigenetics researchers, let’s meet, share, and connect!
14–16 Sep | Adelaide 🇦🇺 | National Wine Centre
Register: 2026aepia.com.au/registration
Abstracts: 2026aepia.com.au/abstracts
#AEpiA2026 #Epigenetics #Chromatin
Some proteins mimic the repressive mark H3K27me3, but the physiological relevance of this phenomenon was unclear. Agius et al. show that the PRC2 subunits JARID2 and PALI1 mimic H3K27me3 to antagonize PRC2-mediated H3K27me3 deposition, limit Polycomb domain spreading, and enable timely activation of developmental genes in vivo.
DNA is scattered with obstacles that stall RNA polymerase II (Pol II) and block the production of full-length transcripts. Two mechanisms are known to resolve stalled Pol II: transcription-coupled nuc...
Optimised nanobody-based quenchbodies are developed through rational design and in vitro evolution, enabling improved protein detection with up to 2.4-fold fluorescence increase and 2 nM sensitivity f...
This fun project was driven by the talented and rigorous Alex Gillis @cftbla.bsky.social, in wonderful collaboration with Ana Tufegdžić Vidaković's @anatv.bsky.social lab!
@singmolsci.bsky.social
@unswrna.bsky.social
What happens when you suddenly remove half of an essential enzyme from cells? 🤔
We watched in real-time as cells deploy multiple backup strategies to buffer against changes in RNA Pol II abundance.
Our lab's new preprint 👇
bit.ly/4pyPgax
