MOE update and window management
For a long time the computational chemistry and molecular modelling package MOE from Chemical Computing Group has required XQuartz to provide the windowing environment. With the introduction...
www.cell.com/cell/abstrac...
If you're in Braunschweig on Thursday... www.helmholtz-hzi.de/en/media-cen...
Erythroid cells, once seen as simple oxygen carriers, actively modulate immunity. CD71-positive erythroid progenitors suppress immune responses in neonates, pregnant women, cancer, autoimmunity, and… PMID:42086867, Nat Rev Immunol 2026, @NatRevImmunol https://doi.org/10.1038/s41577-026-01303-4
ATAC-Seq has become a cornerstone method for studying chromatin accessibility.
Our newest blog, "Charting Open Chromatin Landscapes with ATAC-Seq (Epigenetics Podcast Insights - Part 3)" explores this science further.
Read more: bit.ly/43iEVqL
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#ATACSeq #Epigenetics
Mechanism of K63-linked polyubiquitin recognition and cleavage by the BRCA1-A complex https://www.biorxiv.org/content/10.64898/2026.06.05.730395v1
(Angew Chem) Proximity‐Induced Transfer of a Mass Tag Enables Direct Profiling of Active Matrix Metalloproteases: A proximity-induced, mass-encoded activity-based protein profiling (ABPP) approach transfers a MALDI-detectable α-cyano-4-hydroxycinnamic acid (CHCA) tag… (RSS) #AngewChem #MassSpecRSS
Happy to share the latest macrocycle paper from the Heinis lab, which I was happy to play a small part in during my postdoc. Big congrats to co-first authors Xinjian and Lluc. Now out in @natchembio.nature.com
www.nature.com/articles/s41...
Design principles of a membrane-spanning ubiquitin ligase
Structures of telomerase with allosteric inhibitor BIBR1532 reveal an unexpected mode of inhibition and unique insights into telomerase mechanism
www.nature.com/articles/s41...
Williams et al. report structures of the MMM complex, a membrane-spanning E3 ligase. A single α helix suspends an activated RING domain below the plasma membrane to ubiquitylate the GPCR Smoothened and attenuate Hedgehog signaling. This work establishes a structural and mechanistic blueprint for how transmembrane E3s search and destroy key receptors in development, immunity, and metabolism.
Telomerase, the ribonucleoprotein that maintains telomere ends, is upregulated in most cancer cells, making it a promising oncology target. Cryo-electron microscopy structures of telomerase with allos...
