Many thanks 🙏 to Julie Warin and @anne-grapin.bsky.social for a very nice outlook on our paper in @genesdev.bsky.social
genesdev.cshlp.org/content/earl...
Simona Chera & Cell Fate Lab
Today I'm posting a new blog about an astonishing scientific own goal. Hundreds of papers have reported using a totally wrong antibody to investigate the tumor suppressor p16. This mistake has happened because scientists have muddled the names of two proteins.
forbetterscience.com/2026/06/02/m...
Sholto David
Happy to share our work on characterizing pancreas adaptations during pregnancy in the pig. Our pig cohort allowed us to stratify between early and late pregnancy samples in a model resembling the human pregnancy in terms of gestation time and metabolism. www.biorxiv.org/content/10.6... #PancSky
Excellent work 👏 by @unger-lucas.bsky.social explaining his work in under 2 minutes movie:
Mount Fuji from space.
Marthe Gautier est à l’origine de la découverte du chromosome surnuméraire de la trisomie 21, anomalie génétique qui touche 50 000 personnes en France. À l’occasion de la Journée mondiale de la trisomie 21, retour sur le parcours de cette scientifique invisibilisée, avec la biologiste Julie Batut.
😀
see also www.nature.com/articles/s41...
🆕 ADVANCE ONLINE 🆕
RESEARCH PAPER: Defective HNF1A hinders GLI3 processing favoring duodenal versus pancreatic fate, thus leading to intestinal elongation in vivo
By Unger et al. Luiza Ghila, and Simona Chera
➡️ https://ow.ly/8oTf50YVMEt
Simona Chera & Cell Fate Lab Lucas Unger Luiza Ghila
www.biorxiv.org
@sholtodavid.bsky.social
Have you seen this WB from ThermoFisher?
Still anti-p53 antibody, but another clone (MA-12648 instead MA5-12557).
It also looks like that the band in lane 3 was rotated and reused in lane 4.
Moreover, it seems that same band was used for the 2 different clones.
Cas12a2 enables RNA-triggered, sequence-specific killing of eukaryotic cells via widespread DNA shredding, allowing selective elimination of cells on the basis of gene expression, including virus-infe...
Great paper on developmental gene expression patterns underlying species-specific cortical features (with a nice combination of tools and datasets)
By @itsmeawais.bsky.social @estherkli.bsky.social @djabaudon.bsky.social @silvianeuro.bsky.social @mveronicapravata.bsky.social and colleagues 🧪🧠🧬
CNRS
Genes & Development
Alexis Verger 🧬🧫🧪
Johan Duchêne
📽️ G&D Tapes 📽️
G&D Author, Lucas Unger, tells us about an auto-regulatory loop between HNF1A and Hedgehog signaling that dictates stem cell lineage specification.
New in #genesdev:
➡️ https://genesdev.cshlp.org/content/40/11-12/805.full
Simona Chera & Cell Fate Lab Lucas Unger Luiza Ghila
Video
Machine learning analysis of cell-type-specific gene expression in mouse and human neocortex and human cortical organoids reveals human-specific cell-type and temporal variations in expression control...
New pre-print 📣 “Undruggable” cancer mutations remain very hard to target with current modalities. What if we could instead sense mutant transcripts and convert that recognition into selective cell killing?
Check out this work led by postdoc Jingkun Zeng:
www.biorxiv.org/content/10.6...
