Deletion of badR and replacement of eight conserved residues with alanines in CsrA of resulted in Borrelia burgdorferi mutants with upregulation of RpoS and several immunogenic lipoproteins, that were incapable of colonization in mice.
journals.asm.org/doi/10.1128/...
#MicroSky
The wild, wild west of plasmids: First insights into comparative genomics of Borrelia burgdorferi sensu lato
journals.plos.org/plosone/arti...
pubmed.ncbi.nlm.nih.gov/42102105/
#MicroSky
Lyme disease is the most common vector-borne disease in the United States with 89,000
cases reported to the Centers for Disease Control and Prevention (CDC, Atlanta) in
2023. It is estimated that arou...
On Borrelia burgdorferi lipids:
A lipid compendium of a metabolically compromised bacterium provides insights into lipid acquisition, biosynthesis, and metabolism
www.biorxiv.org/content/10.6...
#MicroSky
Just announced!
This year’s Tick Borne Disease Research Program of CDMRP.
cdmrp.health.mil/funding/tbdrp
#MicroSky
When Clades Collide: Genomic Admixture in Blacklegged Ticks (Ixodes scapularis) from the Great Plains
"~50% infection rate (of B. burgdorferi) in ticks from Iowa and northeastern Nebraska, whereas ticks from Kansas show no evidence of B. burgdorferi infection"
www.biorxiv.org/content/10.6...
“New Concepts in Prokaryotic Virus-Host Interactions”
🗓️ 5–7 October 2026
📍 Harnack House, Berlin, Germany
#MicroSky
Met up with old friends from Yale postdoc days during our recent holiday in England. Included an exciting tour of the genomics facilities at Royal Marsden Hospital / Institute for Cancer Research, where Mike is Scientific Director & Professor.
@generoom.bsky.social
To Move or Not to Move: When and How Bacteria Suppress Flagellar Motility
onlinelibrary.wiley.com/doi/full/10....
#MicroSky
NIH awards the University of Kentucky $11.3 million for COBRE Phase 2 pharmaceutical research
Pleased to be a part of this continuing research program
uknow.uky.edu/research/nih...
Wash cycle complete!
At the Institute for Cancer Research / Royal Marsden Hospital with @generoom.bsky.social
The University of Kentucky has been awarded a prestigious $11.3 million Phase 2 Centers of Biomedical Research Excellence (COBRE) grant from the National Institute of General Medical Sciences of the N...
📢 Registration for our International Symposium on “New Concepts in Prokaryotic Virus-Host Interactions” is now open!
🗓️ 5–7 October 2026
📍 Harnack House, Berlin, Germany
➡️ Information and registration: spp2330.de/symposium-20...
Finally caught up with Borrelia guru, friend and former partner in crime on the rubgy pitch, @bstevensonlab.bsky.social after a (very) long time.
Beers were had 🍺
We need to get a bigger labcoat for next time.
😃
Mike Hubank
New Concepts in Prokaryotic Virus-Host Interaction
