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My lab is currently recruiting 2(!!) postdocs in RNA structural biology/biochemistry! Full details can be found below and on our website (sites.lsa.umich.edu/keane-lab/op...).
3d
Sarah Keane
1d
It may be real, but I'm suspecting that it may not be the same U1 involved in splicing but rather one of the other U1 variant genes (there are many in humans) that for some reason or another isn't able to assemble a Sm ring. It may be a good idea to isolate the U1/U3 hybrid & sequence the snRNA...
Sort of shocked that Sm proteins aren't mentioned in the paper. The U1 snRNA site they identify overlaps with the Sm protein binding site...Seems important? In addition Figure 4j is a bit surprising...
1d
We just published our new paper about an active Helitron transposon in wheat 🌾🧬 We found that it can be mobilised by heat stress when DNA methylation is reduced. We document its full lifecycle: RNA -> circular DNA -> integration www.nature.com/articles/s41... #TEsky