Huh... some head scratching here...
www.biorxiv.org/content/10.6...
A U1-U3 snRNA-snoRNA interaction couples SF3B1 mutation to chromatin-state rewiring and genome instability
Peng Xia, , Omar Abdel-Wahab, Bei Liu, Chuan He et al...
Mutations in spliceosome factors such as SF3B1 are recurrent across human diseases, including myelodysplastic syndromes and leukemia, yet splicing defects alone do not fully explain the widespread chr...