Leaving our #EACR congress in Lisbon appreciating both the incredible science and the amazing community we have - with many wonderful friends!
#EACR2025 🤩
@helloeacr.bsky.social
@adaptmet.bsky.social
@msmelanoma.bsky.social
@arkaitzcarracedo.bsky.social
@svanharanta.bsky.social
Out @nature.com: Clonal tracing with somatic epimutations
🧬 Single cell methylome encodes cell state & clonal identity
🔨 EPI-Clone reads out both (+mutations, +RNA) at scale
🩸 Clonal expansions of HSCs are universal from age 50, not driven by CH mutations
doi.org/10.1038/s415...
🧵
Come join us and @svanharanta.bsky.social @cedric-blanpain.bsky.social Roger Gomis @irbbarcelona.bsky.social @obenaufa.bsky.social Karin de Visser @nkinl.bsky.social @grauperalab.bsky.social @prat-aleix-md.bsky.social @vickysanzmoreno.bsky.social @johannajoyce.bsky.social @momobentires.bsky.social
I am delighted to share our new study uncovering the role of innate immunity in regulating cell plasticity and reprograming of prostate tumor initiating cells published in
@NatureCancer
. Congrats
@ChenJiang919
and
@yura__song
, the first authors,
www.nature.com/articles/s43...
Johanna Joyce
Lars Velten
Kristian Pietras lab
So happy to see that Nature Cancer had chosen our picture as the cover of their September issue together with the publication of our paper on stem cell plasticity during prostate tumor initiation. Congratulations to @ChenJiang919 and @yura__song
Thanks a lot to Alejandro Sifrim (KUL) that co-supervised this work with me, Sandrine Rorive (Curepath), who performed the pathology examination and all our other collaborators.
The discovery that DNA methylation of different CpG sites can serve as digital barcodes of clonal identity led to the development of EPI-Clone, an algorithm that enables single-cell lineage tracing th...
Blanpain and colleagues delineate lineage reprogramming following PTEN deletion in different prostate cancer-originating cells, demonstrating that in basal cells the NF-κB pathway and innate immunity ...
