New Article: "H3K36 methylation stamps transcription resistive to preserve development in plants" rdcu.be/efNVu
New chromatin state, transcription resistive, different from activation & silencing, marked by H3K36me, needs interplay between SDG8 and other H3K36me MTs.
Enhancer cooperativity can compensate for loss of activity over large genomic distances www.cell.com/molecular-ce...
We are happy to share the development of Co-transcriptional Structure Tracking by @leoschaerfen.bsky.social, which measures RNA structure formation during its synthesis in vivo. We are excited to discover the activity of helicases on nascent rRNA!
www.biorxiv.org/content/10.1...
Valentine's Dino-grams for you, your lab mates, and your loved ones! 💖 Print and share all of them here: plasmidsaurus.com/o/valentines... (2/2)
Online Now: Tripartite phosphorylation of SPT5 by CDK9 times pause release and tunes elongation rate of RNA polymerase II Online now:
VACANCY - Are you a molecular biologist and looking for a postdoc?
Join Peter Kindgren's group @umeaplantscicentre.bsky.social and generate superior plants in terms of biomass and stress resilience.
Read more here and apply:
slu.se/en/about-slu...
#PlantSciJobs #PlantSciJob #hiring #plantscience
Gene regulation involves thousands of proteins that bind DNA, yet comprehensively mapping these is challenging. Our paper in Nature Genetics describes ChIP-DIP, a method for genome-wide mapping of hundreds of DNA-protein interactions in a single experiment.
www.nature.com/articles/s41...
UK is cold 🥶
The best thing about FACS sorting is that it provides the best time for reading.
Thomas, Feng, et al. introduce a synthetic platform that allows the building of complex
regulatory landscapes. Integrating the same enhancer at different distances from a
promoter uncovered that activ...
An RNA′s catalytic, regulatory, or coding potential depends on RNA structure formation. Because base pairing occurs during transcription, early structural states can govern RNA processing events and d...
Sun and Fisher performed chemical-genetic dissection of the conserved transcription elongation factor SPT5 in human cells, which revealed that CDK9 phosphorylates three distinct regions in SPT5 that coordinately regulate RNA polymerase II pausing, elongation rate, pre-mRNA splicing, and termination to ensure productive transcription and cell viability.
