ASAP Team Jakobsson is interested in studying the role of transposable elements in Parkinson's disease pathogenesis | Core leadership: Johan Jakobsson (LU), Agnete Kirkeby (UCPH), Molly Gale Hammell (NYU) & Roger Barker (Cambridge University)
ASAP Team Jakobsson
Have a look at two of the latest outputs from CRN Team Jakobsson, examples of true team effort and collaboration 🧠 💫
We are grateful to @asapresearch.parkinsonsroadmap.org for making this research possible!
@jakobssonlab.bsky.social @kirkebylab.bsky.social @mollygale.bsky.social #RogerBarkerLab
Always a joy to join #EMBOMobileGenome -A week full of cool nature’s quirks and science along the friendliest crowd 🧬 Happy to have shared our work on ERVs in human brain evolution (talk by @jakobssonlab.bsky.social) and Parkinson’s disease (poster by yours truly) 🧠
#ASAP @jakobssonasap.bsky.social
Agnete Kirkeby’s 2025 Edinburgh Parkinson’s Lecture is available online: youtu.be/EtuRHdPX4rc?...
She delivered a masterclass on stem cell therapies for #Parkinsons. A PwP told me : “I was expecting not to understand much, but I understood everything!” @kirkebylab.bsky.social @parkinsons.org.uk
CRN Teams Cragg & Jakobsson's new #preprint maps the cell-type–specific transcriptional landscape of the parkinsonian striatum in mouse models and human Parkinson's stages, revealing widespread gene expression changes and resilient neuron subtypes amid progressive dopamine loss 🧪
🔗 bit.ly/4ju4MmS
Excited to share that our team is joining ASAP CRN @asapresearch.parkinsonsroadmap.org! We look forward to collaborating with scientists globally to catalyze breakthroughs in Parkinson’s & accelerate discoveries that lead to new treatments.
Explore more: asapcrn.org #ParkinsonsDisease
@raquelgarza.bsky.social from the Jakobsson Lab presented our recent work on single-cell omics (transcriptomics+ proteomics) within our ASAP project at the SciLifeLab Lund day. This work is being done in collaboration with #BioMS and @scilifelab.se. We are looking forward to the discoveries ahead 🌟
📣 New preprint from the Jakobsson lab!
We describe a detailed protocol to inhibit the expression of transposable elements in human pluripotent stem cells, developed thanks to @asapresearch.parkinsonsroadmap.org funding.
Special shoutout to @anitaada.bsky.social!
www.biorxiv.org/content/10.1...
Are you interested in achieving efficient silencing of transposable elements using CRISPRi? 🧬 🧫
Go ahead and have a look at this STAR protocols where Adami et al. share all the tips & tricks they use in the Jakobsson lab.
@anitaada.bsky.social @raquelgarza.bsky.social @jakobssonlab.bsky.social
Have a look at the new preprint from Team Cragg! We are very happy of having contributed to this great work as a collaboration within the ASAP-CRN network 🧠🔬
@craggasap.bsky.social @asapresearch.parkinsonsroadmap.org
🚨 Have a look at our new preprint: www.biorxiv.org/content/10.1...
A highly collaborative effort where we show that transposable elements are directly linked to a cell-type and region specific inflammatory state in Parkinson’s Disease.
@asapresearch.parkinsonsroadmap.org
Here, we present a workflow for transcriptional silencing of transposable elements
(TEs) in human induced pluripotent stem cells (hiPSCs). We describe steps for designing
guide RNAs (gRNAs) to target ...
This protocol describes the workflow for transcriptional silencing of transposable elements (TEs) in human induced pluripotent stem cells (hiPSCs). The protocol illustrates how to design gRNAs to targ...
Parkinson's disease (PD) is a common age-related neurodegenerative disorder involving a neuroinflammatory response, the cause of which remains unclear. Transposable elements (TE) have been linked to i...
New #publication and #preprint from @jakobssonasap.bsky.social!
⬅️ L1 retrotransposons in stem cells & organoids link L1s to CNS development 🔗 bit.ly/3XyLvGz
➡️ Transposable elements activate in the #Parkinsons brain, tied to interferon responses & a new pathological process 🔗 bit.ly/3LKC5Fo
📣 New preprint alert 📣
A new collaborative study from @meletis.bsky.social and @jakobssonasap.bsky.social on mapping the molecular changes in the mouse and human striatum in #Parkinsons! Congratulations to Marta Graziano and Ioannis Mantas for spearheading this fantastic work!
#OpenScience
💥 New preprint! 💥
We show that transposons are directly linked to a cell-type and region specific inflammatory state in Parkinson’s Disease 🧠🦠
What a team @jakobssonasap.bsky.social! Funded by @asapresearch.parkinsonsroadmap.org
#Parkinsons #Neuroinflammation #TEworldwide #singlecell #TEs
