Super excited that this manuscript investigating verapamil potentiation of bedaquiline in M. tuberculosis is now in PNAS!! Great collaborative effort with Lalita Ramakrishnan and her team at the MRC-LMB!!
www.pnas.org/doi/10.1073/...
@pnas.org
@universityofotago.bsky.social
Really excited that our group was able to contribute to this awesome work from Bing Zhang and Zihe Rao solving the structure and assembly of the MmpS5L5 efflux pump from Mtb!!
www.nature.com/articles/s41...
Bedaquiline is the cornerstone of a new regimen for the treatment of drug-resistant
tuberculosis. However, its clinical use is threatened by the em...
www.pnas.org
The MmpL5/MmpS5 efflux system is crucial for drug extrusion and siderophore export in M. tuberculosis. Here, the authors report its high-resolution cryo-EM structures, revealing a unique trimeric asse...
Really excited that our group was able to contribute to this work showing that the dormancy regulon of M. tuberculosis experienced reductive evolution as it adapted to human populations. Great work led by Sarah Dunstan and Matt Silcocks!!
www.nature.com/articles/s41...
Excited that our group was able to contribute to this awesome work led by Richard Payne and Isabel Barter exploring the how different ClpC1 targeting peptides can have distinct impacts on the proteome of Mycobacterium tuberculosis.
www.nature.com/articles/s41...
Matt McNeil
Matt McNeil
Delighted our study (7+ years in the making) is out today in Nature. In a nutshell, 48 hours of antibiotics in week 1 led to impaired vaccine responses up to 15 months later in infants. We show (in-vivo) a probiotic can fix it #microbiome #science #immunology
www.nature.com/articles/s41...
Mycobacterium tuberculosis owes its success partly to its ability to enter a ‘dormant’, non-replicative state, reactivating years or even decades after initial infection. In this work, authors find th...
In this work, the authors reveal that three non-ribosomal peptides targeting a common protein quality system differentially alter the Mycobacterium tuberculosis proteome, providing new insight into th...
Neonatal antibiotic use is shown to reduce immune response to infant vaccines, accompanied by reduced abundance of Bifidobacteria in the gut microbiota, with experiments in mice indicating that probio...
