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Super excited that this manuscript investigating verapamil potentiation of bedaquiline in M. tuberculosis is now in PNAS!! Great collaborative effort with Lalita Ramakrishnan and her team at the MRC-LMB!! www.pnas.org/doi/10.1073/... @pnas.org @universityofotago.bsky.social
Apr 24, 2025
www.pnas.org
Bedaquiline is the cornerstone of a new regimen for the treatment of drug-resistant tuberculosis. However, its clinical use is threatened by the em...
Verapamil and its metabolite norverapamil inhibit the Mycobacterium tuberculosis MmpS5L5 efflux pump to increase bedaquiline activity | PNAS
Matt McNeil