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💭 Neuroscience. Microbiome. Optogenetics. 📍APC Microbiome Ireland. University College Cork. 👤 Lecturer. Co-chair, UCC Race Equality Network. Director, ALBA Network. SciComm Coord., EU COST AFFECT-EVO. 📜 https://research.ucc.ie/profiles/[email protected]
Jatin Nagpal









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Gut bacterial metabolism of steroid hormones Gut bacterial pathway involving OsrABC reduces natural & synthetic steroid hormones, including anti-inflammatory prednisolone. This microbial activity is enriched in Crohn’s disease patients & diminishes drug bioavailability www.cell.com/cell-host-mi...
7mo
www.science.org/doi/10.1126/...
6mo
Cell Host & Microbe
What is the best brain to study disorders of behavior? Great discussion at @ecnp.eu moderated by @jatinnagpal.bsky.social with inputs from @ribeirocarlitos.bsky.social @emreyaksi.bsky.social @eknapska.bsky.social & Hannah Clarke #ecnp2025
🚀 #ALBADiversityWeek 2025 starts today! We celebrate diversity & intersectionality by highlighting key activities and sharing valuable resources. 👀 Stay tuned all week as we revisit achievements and launch new initiatives. Share our posts to join the #GlobalDiversityAwarenessMonth celebration. 🧵
New essay in @currentbiology.bsky.social special brain-body issue! Fly lab meets psychiatrist: how bodily signals shape cognition and mental health. Great collaboration with Albino Oliveira-Maia showing @champalimaudf.bsky.social discovery ↔️ clinic at its best. www.cell.com/current-biol...
Jatin Nagpal
Jacoby et al. identify a gut bacterial pathway that reduces natural and synthetic steroid hormones, including the anti-inflammatory drug prednisolone. This microbial activity is enriched in Crohn’s di...
Gut bacteria metabolize natural and synthetic steroid hormones via the reductive OsrABC pathway
www.cell.com
8mo
Reaffirming the value of model organisms in training scientific minds | @natcellbio.nature.com www.nature.com/articles/s41...
Had a great time discussing ‘What brain is the best to study disorders of behaviour’. Thanks to my fellow panelists and the audience for an enagaging session at European College of Neuropsychopharmacology (ECNP) 2025 meeting in Amsterdam. #ECNP2025
Great to see our review on microbiome, exposome and cognitive development out in @annualreviews.bsky.social. @apcmicrobiomeirel.bsky.social @uccresearch.bsky.social #MicrobiomeSky #Gut-Brain
7mo
8mo
Very excited to share this finding from my postdoctoral work that is now published in #ScienceAdvances. We show how the gut’s epithelium modifies enteric behaviors during nutritional adversity via distinct peptidergic signaling axes. www.science.org/doi/10.1126/... Thread ⬇️ (1/n)
I'm officially an expert in failing! I was asked to give the opening keynote today for a @cruk-ci.bsky.social conference, speaking on the topic "Failing in Science" youtu.be/BdrTzYcT7MY?...
Intermittent fasting enhances cognition in Alzheimer’s disease via gut microbial indole-3-propionic acid activating neuronal PXR.
www.science.org
Gut microbial-derived indole-3-propionate improves cognitive function in Alzheimer’s disease
8mo
8mo
9mo
8mo
1mo
John F. Cryan
ALBA Network
YouTube video by Adrian Liston
youtu.be
Failing in science
Jatin Nagpal
Jatin Nagpal
Carlos Ribeiro
Jatin Nagpal
Surojit Sural
Adrian Liston
www.cell.com
Carlos Ribeiro and Albino Oliveira-Maia propose how brain–body interactions may inform the study of ‘higher’ cognitive functions such as learning and memory across model systems.
From cognition in the body to the body in cognition
What is the best brain to study disorders of behavior? Great discussion at @ecnp.eu moderated by @jatinnagpal.bsky.social with inputs from @ribeirocarlitos.bsky.social @emreyaksi.bsky.social @eknapska.bsky.social & Hannah Clarke #ecnp2025
8mo
John F. Cryan
Gut epithelium modulates output from distinct enteric circuits by altering secretion of insulin and noninsulin peptides.
www.science.org
Gut epithelium modifies enteric behaviors during nutritional adversity via distinct peptidergic signaling axes
What are the many “known unknowns” on the microbiome, exposome, & cognitive development? @maburto.bsky.social @jatinnagpal.bsky.social @jfcryan.bsky.social https://loom.ly/oUMFc0w
9mo
Gut Microbiota for Health
The gut microbiota, composed of trillions of microorganisms, plays a key role in bidirectional communication between the gut and brain, particularly during early life. The first two postnatal years represent a critical window when the exposome—the totality of all environmental exposures—shapes neurodevelopment via the microbiota–gut–brain axis. Exposome factors such as diet, birth mode, antibiotic use, infections, and xenobiotics can alter microbial composition and function, with downstream e...
www.annualreviews.org
Microbiome, Exposome, and Cognitive Development: The Known Unknowns | Annual Reviews