Sr Research Fellow, Jay Shin Lab, Genome Inst Singapore. Collab Bruno Reversade Lab
PhD Eric Miska & Azim Surani Labs, Gurdon Inst, Cambridge
Biochem Grad, Oxford
Views are my own
Navin B. Ramakrishna
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New paper out in @cp-cellstemcell.bsky.social. We uncover unexpected complexity in how metabolism changes when the embryo implants or when stem cells exit naive pluripotency, revealing a central role for dynamic TCA cycle rewiring in cell fate decisions. www.cell.com/cell-stem-ce...
🚨 Why can’t mammals regenerate limbs like frog tadpoles or salamanders?
In our new paper in @science.org , we show that species-specific oxygen sensing acts as a gatekeeper for initiating limb regeneration 🐭🐸
🔗 www.science.org/doi/10.1126/... #EvoDevo
Using carbon tracing and functional experiments, Kafkia, Pladevall-Morera, et al.
show that TCA cycle rewiring underlies mouse embryo implantation and the exit from
naive pluripotency. In this context...
Why mammals cannot regenerate limbs like amphibians do presents a long-standing puzzle in biology. To uncover the underlying differences, we compared amputation responses of embryonic mouse (Mus musculus) and Xenopus laevis tadpole limbs. Lowering ...
Online Now: Gut microbiota modulation of regulatory DNA elements revealed by massively parallel functional characterization Online now:
Saddened to learn of the death of Greg Hannon, a former CSHL colleague and giant of modern molecular biology www.cruk.cam.ac.uk/news/in-memo...
A biochemical curiosity: it is much more straightforward to go enzymatically from 5mC > T than it is to go from 5mC > C
Absolutely thrilled 💣 to share our preprint 🖨️: "Mapping active cis-regulatory elements from transcription initiation events”.
www.biorxiv.org/content/10.6...
We introduce nucCAGE and PRIME to identify active cis-regulatory elements (CREs) and disease-associated, non-coding variants.
To maintain metabolic homeostasis, the liver rapidly adjusts gene expression in response to nutrients, endotoxins, and microbial metabolites derived from the gut. Zaratiana et al. identify microbiota-responsive cis-regulatory elements in hepatocytes. Their results suggest that microbial metabolites modulate the activities of host regulatory DNA elements to shape hepatocyte transcriptional programs.
dlvr.it
Meet our Preprint Editors
We are pleased to welcome our first group of Preprint Editors to our editorial team, responsible for handling our 'In preprints' articles. #preprints
journals.biologists.com/dev/pages/ed...
Greg was already a world-renowned scientist when appointed Director, and for the community, he was a visionary leader, a cherished mentor, and a singular force of nature whose influence shaped the research landscape.
Human embryo editing against disease is unsafe and unproven — despite rosy predictions www.nature.com/articles/d41...
Paying peer reviewers works.
Expanded Fast & Fair experiment @biologyopen.bsky.social:
• 5.5 vs 37.7 working days to decision with reviews
• ~3 vs ~9 reviewer invitations per manuscript
• no reduction in editor-assessed review quality
• similar acceptance rates
www.biorxiv.org/content/10.6...
Richard Sever
Published in @natmed.nature.com today, Stephen Mayhew, Dave Allan and David Roblin share ten lessons learned from a decade of translating science at the Crick towards health and societal impact.
www.nature.com/articles/s41...
www.biorxiv.org
Maxim Greenberg
Robert Krautz
Development
Pitfalls of heritable genome editing undermine theoretical benefits.
Those amazing #phages 🦠 figured out 5mC chemistry before we did:
📄 Out today in @MolecularCell we describe a 5mC-selective #deaminase family in environmental phage genomes with broad applications for #5base #sequencing
#epigenetics #DNAmethylation #genomics #NGS 🧬🧪
www.cell.com/molecular-ce...
