Our May issue is here! rupress.org/jgp/issue/15... The cover represents beat-locked mitochondrial ATP consumption in a sinoatrial node pacemaker myocyte. From Muñoz, @lfsantana68.bsky.social and colleagues: doi.org/10.1085/jgp....
In this #TopicalReview, Nathan Grainger of @unevadareno.bsky.social
discusses the role of resident #pacemaker cells in the #renal pelvis and argues that a greater understanding of pacemaker and peristaltic mechanisms is warranted 🔬 🔎
Read it here:
📜 physoc.onlinelibrary.wiley.com/doi/10.1113/...
Beat-locked ATP microdomains in the sinoatrial node map a Ca2+-timed energetic hierarchy and regional pacemaker roles. New study from Manuel F. Muñoz, Fernando Santana @lfsantana68.bsky.social and colleagues @ucd-physiology.bsky.social rupress.org/jgp/article/...
#IonChannels #CardiacMuscle
Very happy to share our latest work out in PNAS this week, led by Amy Xiang.
We show that capillary thin-strand pericytes express TMEM16A calcium-activated chloride channels, which set the operating point for capillary control of cerebral blood flow in vivo.
www.pnas.org/doi/10.1073/...
Our new paper is out! 🎉
Let-7 doesn’t act through a single pathway: it controls neocortical neuron fate and migration via distinct downstream mechanisms, with RBX2 dedicated to migration. A new layer of post-transcriptional control shaping cortical development
www.pnas.org/doi/10.1073/...
Join us for the 2026 Carlson Lecture, with speaker Kafui Dzirasa, MD, PhD from Duke U. Medical Center. Learn how engineered neural circuits may restore healthy brain function and help prevent psychiatric disorders. Thursday, June 4th, 12pm, Genome Auditorium
Description: Photo, scientist smiling
Happy Monday everyone!!!
Happy to share this book chapter by my awesome partner
Made Nieves-Cintron and #MnMLab members on
"Experimental Models for Studying Cardiovascular Dysfunction in Metabolic Syndrome"
Highly relevant topic these days!!!
link.springer.com/chapter/10.1...
🚨Not all channels are created equal🚨 New work from our lab shows that PKA regulates vascular CaV1.2 via S1928 — NOT Rad — phosphorylation, overturning the assumption that cardiac and vascular channels are regulated the same way.
www.ahajournals.org/doi/10.1161/...
Tomorrow! June 4—Kafui Dzirasa, MD, PhD from Duke University Medical Center will be our distinguished speaker at the 2026 Carlson Lecture.🎙️🧠 Join us at 12pm in the Genome Auditorium, room 1005.
Description: Portrait photo of the lecture speaker
Compelling new study by @maartjewesthoff.bsky.social, Taylor Voelker, @roseedixon.bsky.social et al. This latest work in Circulation Research explores what happens when angiotensin II signaling becomes chronic. www.ahajournals.org/doi/10.1161/...
Journal of General Physiology
Journal of General Physiology
The Journal of Physiology
Tom Longden
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
BACKGROUND: Contractile dysfunction, hypertrophy, and cell death during heart failure are linked
to altered Ca2+ handling and elevated levels of the hormone AngII (angiotensin II), which signals
throu...
www.ahajournals.org
Metabolic syndrome (MetS) encompasses an interconnected set of risk factors, including abdominal obesity, insulin resistance, hypertension, dyslipidemia, and systemic inflammation, all of which signif...
