New review: Shimon Schuldiner recounts the decades-long journey of VMAT research, bridging foundational bioenergetics with recent high-resolution structural breakthroughs. rupress.org/jgp/article/...
#Neuroscience
Long-term inactivation mediated by different FGF-A homologues on heterologously expressed NaV1.2 currents. New study from Yenisleidy Lorenzo-Ceballos, Christopher J. Lingle @chris-lingle.bsky.social and colleagues @washumedicine.bsky.social:
rupress.org/jgp/article/...
#Biophysics #IonChannels
JGP study from Lukyanenko et al. (rupress.org/jgp/article/...) shows that, in the absence of full-length dysferlin, its C2A domain alone can support normal Ca2āŗ signaling and sarcolemma repair, suggesting that it could be used in gene replacement therapies. rupress.org/jgp/article/...
A kinetic trap mechanism underlies hHv1 inhibition by NZ-58. New study from Adam Feher (University of Chicago), Zoltan Varga (University of Debrecen) and colleagues
rupress.org/jgp/article/...
#CellularPhysiology #MolecularPharmacology #MembraneTransport #IonChannels
Publishing in JGPĀ enables authors funded by National Institutes of Health (NIH), Howard Hughes Medical Institute (HHMI), and other funders an easy pathway to compliance. Learn more:
š rupress.org/pages/nih-hh...
Join us for the next SGP EpIC Seminar on Tuesday, 2 June 2026, at 12:00 pm Eastern featuring a talk by Wojciech Kopec on āComputational electrophysiology of potassium channels.ā As ever, registration is free and all are welcome: sgp-epic-seminars.com
Publishing in JGPĀ enables authors funded by National Institutes of Health (NIH), Howard Hughes Medical Institute (HHMI), and other funders an easy pathway to compliance. Learn more:
š rupress.org/pages/nih-hh...
š£ Call for Papers! š£ We welcome papers on Voltage-Gated Sodium Channels for a special issue, initiated in the context of the second Worldwide Sodium Channel Conference #WSCC26 in Switzerland, February 4 - 6, 2026. Submit here š rupress.org/jgp/pages/ca...
#IonChannels #CallForPapers
Adam Feher, Zoltan Varga et al. examine the molecular mechanism of NZ-58, a novel hHv1 inhibitor. Their findings suggest that it binds to the upper gating triad containing countercharges D112 and D185, leading to a ākinetic trappingā mechanism of inhibition. rupress.org/jgp/article/...
#IonChannels
Model of ocular surface ion and water transport predicts efficacy of #DryEye therapeutics. New study from Varun Verma @ucberkeleyofficial.bsky.social, Alan S. Verkman (UCSF) and colleagues:
rupress.org/jgp/article/...
#CellBiology #MembraneTransport #ComputationalBiology
