Online Now: Hypoxia-induced ribosomal RNA modifications in the peptidyl-transferase center contribute to anaerobic growth of bacteria Online now:
Ishiguro et al. identify stereoselective ribose-backbone methylations in the peptidyl-transferase center of E. coli ribosomes, installed by the cobalamin-dependent enzyme RlmX. These methylations, together with ho5C2501, are specifically induced under hypoxia. The hypoxia-induced modifications activate ribosomes, enhancing translational capacity and thereby promoting bacterial fitness in anaerobic conditions.dlvr.it
Postdoc positions available in the Heick Jensen lab in sunny Aarhus. Sorting of good and bad RNAs in mammalian nuclei. Please get in touch for further information and/or use the following link to apply:
mbg.au.dk/en/news-and-...
Message to my 11 followers in Bluesky:
We are pleased to announce that registrations for the International EMBO workshop Ribosome Synthesis: from Mechanisms to Therapy 13th Edition are now open!
Details and registration: www.eventsforce.net/hg3/frontend...
The Organizing Committee
Excited to share this one! We developed an in vivo model for specific manipulation of transfer RNA acetylation and found it serves as a sentinel modification whose loss causes ribosome stalling and stress signaling. Implications for a genetic disorder and cancer.
www.science.org/doi/10.1126/...
New preprint from us!
We find that disruption of the mRNA m6A writer complex triggers autoimmunity in Arabidopsis –
www.biorxiv.org/content/10.1...
Message to my 11 followers in Bluesky:
We are pleased to announce that registrations for the International EMBO workshop Ribosome Synthesis: from Mechanisms to Therapy 13th Edition are now open!
Details and registration: www.eventsforce.net/hg3/frontend...
The Organizing Committee
Vacancy at Department of Molecular Biology and Genetics - RNA Biology and Innovation, Aarhus University
Distinguishing self from non-self is crucial to direct immune responses against pathogens. Unmodified RNAs stimulate human innate immunity, but RNA modifications suppress this response. mRNA m6A modif...
www.biorxiv.org
Torben Heick Jensen
Very happy to see our work, "The implication of non-AUG-initiated N-terminally extended proteoforms in cancer," in this special collection of RNA Biology! 💫 Thanks to @lafontainelab.bsky.social and TRANSLACORE for the opportunity to contribute to this collection!
www.tandfonline.com/journals/krn...
Denis LJ Lafontaine
Anders H. Lund
Jordan Meier
Gordon Simpson
Explore the article collection: TRANSLACORE, a European network to coordinate research on translation regulation in cancer. Published in RNA Biology.
Ni, Wei, Vona and colleagues use human brain organoids to dissect patient AIRIM variants associated with neurodevelopmental features. A subset of variants impaired ribosome production and protein synt...
