RNA Biologist
Ribosome biogenesis dysfunction diseases
Structure-Function relationships in the Nucleolus
Biomolecular condensates
www.lafontainelab.com
Denis LJ Lafontaine
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Spending quality time with good friends at the #Helicase conference in beautiful Lisbon #RNA
Message to my 11 followers in Bluesky:
We are pleased to announce that registrations for the International EMBO workshop Ribosome Synthesis: from Mechanisms to Therapy 13th Edition are now open!
Details and registration: www.eventsforce.net/hg3/frontend...
The Organizing Committee
come join!
How has native RNA sequencing contributed to epitranscriptomic research? This is one of the main questions we addressed in our recent review by @evamarianovoa.bsky.social and I now live in Molecular Cell #RNAsky #RNA #nanopore
authors.elsevier.com/a/1kS2f3vVUP...
www.nature.com/articles/s41...
Excited to share this one! We developed an in vivo model for specific manipulation of transfer RNA acetylation and found it serves as a sentinel modification whose loss causes ribosome stalling and stress signaling. Implications for a genetic disorder and cancer.
www.science.org/doi/10.1126/...
Very happy to see our work, "The implication of non-AUG-initiated N-terminally extended proteoforms in cancer," in this special collection of RNA Biology! 💫 Thanks to @lafontainelab.bsky.social and TRANSLACORE for the opportunity to contribute to this collection!
www.tandfonline.com/journals/krn...
New preprint from us!
We find that disruption of the mRNA m6A writer complex triggers autoimmunity in Arabidopsis –
www.biorxiv.org/content/10.1...
Postdoc positions available in the Heick Jensen lab in sunny Aarhus. Sorting of good and bad RNAs in mammalian nuclei. Please get in touch for further information and/or use the following link to apply:
mbg.au.dk/en/news-and-...
Online Now: Hypoxia-induced ribosomal RNA modifications in the peptidyl-transferase center contribute to anaerobic growth of bacteria Online now:
Ni, Wei, Vona and colleagues use human brain organoids to dissect patient AIRIM variants associated with neurodevelopmental features. A subset of variants impaired ribosome production and protein synt...
www.nature.com
An ancient tRNA modification is used by mammalian cells to coordinate protein translation and adaptive signaling.
Distinguishing self from non-self is crucial to direct immune responses against pathogens. Unmodified RNAs stimulate human innate immunity, but RNA modifications suppress this response. mRNA m6A modif...
Ishiguro et al. identify stereoselective ribose-backbone methylations in the peptidyl-transferase center of E. coli ribosomes, installed by the cobalamin-dependent enzyme RlmX. These methylations, together with ho5C2501, are specifically induced under hypoxia. The hypoxia-induced modifications activate ribosomes, enhancing translational capacity and thereby promoting bacterial fitness in anaerobic conditions.
Message to my 11 followers in Bluesky:
We are pleased to announce that registrations for the International EMBO workshop Ribosome Synthesis: from Mechanisms to Therapy 13th Edition are now open!
Details and registration: www.eventsforce.net/hg3/frontend...
The Organizing Committee
