RNA Biologist
Ribosome biogenesis dysfunction diseases
Structure-Function relationships in the Nucleolus
Biomolecular condensates
www.lafontainelab.com
Denis LJ Lafontaine
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Message to my 11 followers in Bluesky:
We are pleased to announce that registrations for the International EMBO workshop Ribosome Synthesis: from Mechanisms to Therapy 13th Edition are now open!
Details and registration: www.eventsforce.net/hg3/frontend...
The Organizing Committee
Spending quality time with good friends at the #Helicase conference in beautiful Lisbon #RNA
Postdoc positions available in the Heick Jensen lab in sunny Aarhus. Sorting of good and bad RNAs in mammalian nuclei. Please get in touch for further information and/or use the following link to apply:
mbg.au.dk/en/news-and-...
Denis LJ Lafontaine
come join!
Vacancy at Department of Molecular Biology and Genetics - RNA Biology and Innovation, Aarhus University
Online Now: Hypoxia-induced ribosomal RNA modifications in the peptidyl-transferase center contribute to anaerobic growth of bacteria Online now:
www.nature.com/articles/s41...
Very happy to see our work, "The implication of non-AUG-initiated N-terminally extended proteoforms in cancer," in this special collection of RNA Biology! 💫 Thanks to @lafontainelab.bsky.social and TRANSLACORE for the opportunity to contribute to this collection!
www.tandfonline.com/journals/krn...
New preprint from us!
We find that disruption of the mRNA m6A writer complex triggers autoimmunity in Arabidopsis –
www.biorxiv.org/content/10.1...
Torben Heick Jensen
Ishiguro et al. identify stereoselective ribose-backbone methylations in the peptidyl-transferase center of E. coli ribosomes, installed by the cobalamin-dependent enzyme RlmX. These methylations, together with ho5C2501, are specifically induced under hypoxia. The hypoxia-induced modifications activate ribosomes, enhancing translational capacity and thereby promoting bacterial fitness in anaerobic conditions.
Ni, Wei, Vona and colleagues use human brain organoids to dissect patient AIRIM variants associated with neurodevelopmental features. A subset of variants impaired ribosome production and protein synt...
www.nature.com
Explore the article collection: TRANSLACORE, a European network to coordinate research on translation regulation in cancer. Published in RNA Biology.
How has native RNA sequencing contributed to epitranscriptomic research? This is one of the main questions we addressed in our recent review by @evamarianovoa.bsky.social and I now live in Molecular Cell #RNAsky #RNA #nanopore
authors.elsevier.com/a/1kS2f3vVUP...
Message to my 11 followers in Bluesky:
We are pleased to announce that registrations for the International EMBO workshop Ribosome Synthesis: from Mechanisms to Therapy 13th Edition are now open!
Details and registration: www.eventsforce.net/hg3/frontend...
The Organizing Committee
Distinguishing self from non-self is crucial to direct immune responses against pathogens. Unmodified RNAs stimulate human innate immunity, but RNA modifications suppress this response. mRNA m6A modif...
Excited to share this one! We developed an in vivo model for specific manipulation of transfer RNA acetylation and found it serves as a sentinel modification whose loss causes ribosome stalling and stress signaling. Implications for a genetic disorder and cancer.
www.science.org/doi/10.1126/...
Gordon Simpson
Gregor Diensthuber
An ancient tRNA modification is used by mammalian cells to coordinate protein translation and adaptive signaling.
