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Happy to share our review of the past, recent, and future applications of synthetic genomics in studying the 3D functional organization of chromosomes, a set of approaches that are gaining momentum! www.sciencedirect.com/science/arti...
link.springer.com/article/10.1... Very happy to share the early-access version of our latest paper published in CMLS. @inserm.fr @cnrsbiologie.bsky.social @lbmcinlyon.bsky.social @ensdelyon.bsky.social
11d
1mo
DEAD box helicases DDX17 and DDX5 control transcription termination and the associated processing of the 3' end of pre-messenger RNAs. Here, we demonstrate that the transcriptional readthrough induced...
link.springer.com
The role of genome 3D organization for fundamental chromatin processes, such as long-range promoter-activator regulatory interactions, remains ambiguo…
www.sciencedirect.com
MYCN and helicases DDX17 and DDX5 have opposite effects on the production of readthrough-associated chimeric transcripts - Cellular and Molecular Life Sciences
Synthetic chromosomes for 3D functional genomics: from principles to AI-guided design
Romain Koszul
Cyril Bourgeois
If you have experience in biochemistry/cryo-EM, are interested in DNA replication, and would like to do a postdoc in New York - our lab has positions available! Just DM or email me with your CV.
1d
Everything you always wanted to know about plasmid chromatinization … but were afraid to ask