Online Now: Deciphering the dual effects of transcription on DNA replication elongation by replication-associated Micro-C Online now:
Integrating replication-associated Micro-C and the reinforcement-learning-based computational framework Fun2, Zhangding et al. profile DNA-replication elongation driven by coupled replication forks at nucleosome resolution in mammalian cells and reveal that transcription has dual effects on replication elongation. Co-directional transcription facilitates fork progression, whereas head-on transcription blocks coupled forks.
