Excited to share a preprint from my postdoc work in
Shipman’s lab!
We developed Detectrons — programmable biosensors that convert RNA signals into stable DNA barcodes inside living cells, enabling multiplexed RNA sensing. 🧵👇
biorxiv.org/content/10.6...
High-throughput engineering of ligand-activated splicing ribozyme through domain insertion https://www.biorxiv.org/content/10.64898/2026.05.21.726912v1
A new paper in Science measured the prevalence of social sycophancy across 11 leading large language models. The model’s responses were nearly 50% more sycophantic than humans’, even when users engaged in unethical, illegal, or harmful behaviors.
www.science.org/doi/10.1126/...
Just amazing what evolution can come up with. Naturally occurring nuclease deficient Cas12 family members use gRNAs to bind DNA and recruit sigmaE family members that drive txn initiation proximally. 2 papers! 1- describes 2- structure!
www.nature.com/articles/s41... www.nature.com/articles/s41...
The ERC's new white paper examines the gap in participation and success rates between Europe’s strongest research systems and a group of countries performing less well. It also calls for coordinated efforts at national and European level.
Read more: erc.europa.eu/news-events/...
🤖 Announcement for Opentrons users - OT-2 & Flex 🤖
We developed Slowpoke, an open-source, automated Golden Gate cloning tool with Fankang Meng & @proftomellis.bsky.social at @imperialcollegeldn.bsky.social
Flex-optimisation by @gregorybatt.bsky.social at @pasteur.fr
👉 pubs.acs.org/doi/10.1021/...
Jihoon Han
One of the biggest challenges in microbial biotechnology? Unlocking the potential of non-model microbes and synthetic communities! Glad to share our review @sonjablasche.bsky.social @simonemozzachiodi.bsky.social @kiranrpatil.bsky.social @cambridgebiosci.bsky.social🧵(1/7) doi.org/10.1016/j.co...
bioRxiv Synthetic Biology
European Research Council (ERC)
How diverse is bacterial immunity ?
We report in @science.org how language models allowed us to predict 2.4M antiphage proteins spanning >23K novel potential systems.
👏 @emordret.bsky.social, @alexhv.bsky.social & al doi.org/10.1126/scie...
Explore them here defensefinder.mdmlab.fr/wiki/refseq_...
Koray Malcı
New review out! Bacterial pathogens diversify to survive during infection - using bet-hedging and division of labor to generate specialized subpopulations. We explore how host signal actively drive this process
www.sciencedirect.com/science/arti...
Indra Roux
Jay Van Bavel, PhD
www.science.org
Craig Kaplan
www.sciencedirect.com
Phenotypic heterogeneity within isogenic bacterial populations represents a fundamental adaptation strategy that enables pathogen survival across the …
“Academic science is not only about productivity, it is also about deep understanding, exploring creative solutions and training critical thinkers to be the next generation of researchers.”
www.nature.com/articles/d41...
Artificial intelligence is rapidly accelerating scientific output, but risks narrowing inquiry, weakening judgement and undermining how scientists are trained.
