Exploring the dual nature of signals, particularly Wnt signaling, in homeostasis and cancer using organoids and proteomics to uncover patient-specific mechanisms. Founder of Laigo Bio.
Center for Molecular Medicine | Oncode Institute | madelonmauricelab.nl
Maurice Lab
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In our new iScience paper we find that WNT7B marks specific pancreatic tumour cells that maintain a basal like state and correlate with more aggressive disease. WNT-high cells support the survival of neighbouring cells through cell-cell contact-dependent signalling.
doi.org/10.1016/j.is...
🚀 Big news from the Maurice lab!
OutMARCH has secured an EIC Pathfinder grant to develop SureTACs, bispecific antibodies that degrade cancer driving membrane proteins, including previously undruggable targets. A new precision strategy to overcome therapy resistance in cancer. Thread 👇
We will harness MARCH E3 ligases to selectively remove disease driving surface proteins. By bringing ligase and target together, SureTACs aim to overcome resistance and limit on target off tissue effects. Starting with B cell leukaemia and GI cancers 🔬✨
We are proud to collaborate with Danny Sahtoe (@hubrechtinstitute.bsky.social), Florian I. Schmidt (Bonn University) and Thorsten Zenz (University of Zurich), alongside the team of Laigo Bio.
Want to learn the latest insights on how Wnt signaling controls cell behavior?
Check out a new review by Madelon Maurice (@madelonmaurice.bsky.social) and Stephane Angers at @natrevmcb.bsky.social
Jelte van der Vaart, postdoc in our lab, has been awarded an NWO Veni grant! 🎉
He will develop human adrenal organoids to uncover how hormone producing cells change identity and function, shedding light on endocrine health.
We're so proud of his achievement and will support him along the way 😁
Yesterday, @antonvenhuizen.bsky.social successfully defended his thesis "Molecular mechanisms of the
β-catenin destruction complex in health and disease", which describes the versatile field of WNT regulator AXIN1.
We are super proud and wish Dr. Venhuizen all the best in Cambridge!
Incredibly excited to join forces to develop new and unconventional approaches for #colorectalcancer treatment with the REWIRE-CAN team!
@cancergrand.bsky.social @umcutrecht.bsky.social @oncodeinstitute.bsky.social
@mauricelab.bsky.social
Our Center for Molecular Medicine (cmmutrecht.eu) at UMC Utrecht, NL, is looking for a Principal Investigator in the field of fundamental Cancer Biology! The vacancy states tenure track level, but candidates with a more advanced career are very welcome to apply. shorturl.at/KZeYQ. Please repost!
Excited to share that work from my PhD in the @mauricelab.bsky.social has been published in @cp-iscience.bsky.social.
❔️Why do mutations in two Wnt pathway genes lead to different clinical features in hepatocellular carcinoma?
📄Read the paper for our insights: doi.org/10.1016/j.is...
Maurice Lab
Maurice Lab
Maurice Lab
Maurice Lab
Maurice Lab
Maurice Lab
Maurice Lab
Madelon Maurice
Aniek Janssen
Anton Venhuizen
📰 News announcement! www.cancergrandchallenges.org/new-teams-an...
We’re thrilled to welcome five world-leading scientific teams, each awarded up to £20 million, to take on some of the toughest unanswered questions in #CancerResearch.
Find out more about the teams and their challenges.
