Exploring the dual nature of signals, particularly Wnt signaling, in homeostasis and cancer using organoids and proteomics to uncover patient-specific mechanisms. Founder of Laigo Bio.
Center for Molecular Medicine | Oncode Institute | madelonmauricelab.nl
Maurice Lab
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In our new iScience paper we find that WNT7B marks specific pancreatic tumour cells that maintain a basal like state and correlate with more aggressive disease. WNT-high cells support the survival of neighbouring cells through cell-cell contact-dependent signalling.
doi.org/10.1016/j.is...
🚀 Big news from the Maurice lab!
OutMARCH has secured an EIC Pathfinder grant to develop SureTACs, bispecific antibodies that degrade cancer driving membrane proteins, including previously undruggable targets. A new precision strategy to overcome therapy resistance in cancer. Thread 👇
We are proud to collaborate with Danny Sahtoe (@hubrechtinstitute.bsky.social), Florian I. Schmidt (Bonn University) and Thorsten Zenz (University of Zurich), alongside the team of Laigo Bio.
We will harness MARCH E3 ligases to selectively remove disease driving surface proteins. By bringing ligase and target together, SureTACs aim to overcome resistance and limit on target off tissue effects. Starting with B cell leukaemia and GI cancers 🔬✨
