Scientist. Group leader at the Sanger Institute, Cambridge UK. Somatic mutation and selection in normal tissues, cancer and ageing.
Inigo Martincorena
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We are excited by the potential of human epithelioids for in vitro drug screens and clonal competition studies to reduce the frequency or size of clones carrying cancer-driver mutations in normal tissues, as a new approach for molecular prevention of cancer.
Do not miss this incredible paper from David Fernandez Antoran's team (with some contribution from my team). The paper introduces epithelioids as a powerful 3D culture system for 8 different human tissues, for longitudinal in vitro studies of human epithelia. Great thread from David below.
And my original thread about it, from when it came out as an unformatted Accelerated Article Preview: bsky.app/profile/imar...
Our autoimmunity paper is out today in final form and OA. We found a fascinating landscape of somatic evolution underpinning thyroid autoimmunity, where tens of B cell clones convergently lose immune checkpoints and some acquire 4-6 drivers over years of evolution. www.nature.com/articles/s41...
Inigo Martincorena
Here is the News and Views: www.nature.com/articles/d41...
