Do not miss this incredible paper from David Fernandez Antoran's team (with some contribution from my team). The paper introduces epithelioids as a powerful 3D culture system for 8 different human tissues, for longitudinal in vitro studies of human epithelia. Great thread from David below.
Inigo Martincorena
🚨#Preprint alert! @antoranlab.bsky.social
in close collaboration with @imartincorena.bsky.social lab
www.biorxiv.org/content/10.6...
How can we study human #epithelial tissues for months in the lab, while preserving their native structures and behaviour but without passaging?
www.biorxiv.org
Modeling human epithelia in vitro remains challenging because current systems do not fully preserve the combination of architecture, heterogeneity, clonal composition, and long-term dynamics shown in ...
