New paper out 🚨! Excited to share this collab between my lab and @kerschensteiner.bsky.social's group, expertly led by Ning Shen. We used a genome-wide in vivo CRISPR screen to uncover novel neuroprotective strategies in the P23H mouse retina, with validation in a new human retina culture model.
Phil Ruzycki
Shen et al. combine a genome-wide CRISPR screen in mice with an adult human retina model to identify broadly protective gene therapies for retinitis pigmentosa. They show that boosting UFD1 or UXT preserves photoreceptors and vision by helping the retina withstand stress from misfolded proteins.
Well, the Biology and Development of the Eye (BDE) study section has been postponed (previously scheduled for Thurs/Fri).
I’m very disappointed on behalf of the applicants and reviewers, who all want this meeting to happen. I’m also grateful to the NIH staff who work so hard to make science happen.
