New paper out 🚨! Excited to share this collab between my lab and @kerschensteiner.bsky.social's group, expertly led by Ning Shen. We used a genome-wide in vivo CRISPR screen to uncover novel neuroprotective strategies in the P23H mouse retina, with validation in a new human retina culture model.
Shen et al. combine a genome-wide CRISPR screen in mice with an adult human retina model to identify broadly protective gene therapies for retinitis pigmentosa. They show that boosting UFD1 or UXT preserves photoreceptors and vision by helping the retina withstand stress from misfolded proteins.
