If you're interested in trying out these protocols in your own lab, we are making the cell lines available through @CancerToolsOrg
cancertools.org/cell-lines/...
Our lab has an opening for a new Research Assistant (LSRP) starting this Summer/Fall. If you're interested in joining a vibrant community working at the interfaces of cancer metastasis and adaptive immunity, apply here:
careersearch.stanford.edu/jobs/life-sc...
If you're interested in hearing about lymph node metastasis, tumor evolution, T cells, and immunotherapy, check out this @theNCI forum tomorrow, featuring Mary Jo Turk, @naxerova, and Alexander Huang. events.cancer.gov/dcb/tdln #TDLNForums
Interested in studying lymph node metastasis? Check out our protocol by Cort Breuer out today in @natprot.nature.com
bsky.app/profile/nat...
Lymph node metastasis is almost always synonymous with cancer progression, but in this fantastic study from @ubellackerlab.bsky.social, they reveal that it also imparts a key metabolic vulnerability: FSP1 dependency. Congrats Jess and @mariopalma.bsky.social!
And if you're interested in investigating what is happening in the lymph fluid itself, check out this great protocol by the
@ubellackerlab.bsky.social
www.nature.com/articles/s4...
And the commentary by the great von Andrian lab
bsky.app/profile/nat...
Nathan Reticker-Flynn
New Article! Spontaneous and experimental models of lymph node metastasis
https://bit.ly/4fzWoAj
Excited to share this work from the Garcia Lab out today in @naturecomms.bsky.social! We engineer "cytokine adaptors", molecular immune switches that simultaneously block a target cytokine while inducing local activation of alternative cytokine receptors. rdcu.be/ec7GS
Nathan Reticker-Flynn
Nathan Reticker-Flynn
Nathan Reticker-Flynn
Nathan Reticker-Flynn
Hot off the presses! Was an honor to team up with Scott Dixon @stanforduniversity.bsky.social on this Nature Cancer review. We reflect on hurdles that have slowed translation of ferroptosis-directed therapies and share ideas on what it will take to bring these therapies to the clinic. rdcu.be/eBbqV
Nature Cancer - Ubellacker and Dixon summarize the latest discoveries on ferroptosis in cancer, covering the molecular and cellular pathways underlying sensitivity and resistance to this type of...
Evolution Under Therapy: Resistance Mechanisms—
Andrew J. Aguirre, Nathan Reticker-Flynn, Susan M. Rosenberg, and Kathleen Burkhardt will address this topic in a plenary at the AACR Special Conference on Cancer Evolution (Dec 4-6; Albuquerque).
buff.ly/4ecfgxE
#AACRevol25 @retickerflynn.bsky.social
Sixth generation cell line derived from an ipsilateral axillary lymph node metastasis of a fifth-generation line
Stanford University is seeking a Life Science Research Professional 1 to perform basic functions and activities involved in defined research projects....
Nature Protocols - An approach to collect lymph drained from the primary tumor in mice enables the downstream characterization of the samples using metabolomics, lipidomics and flow cytometry.
Ferroptosis-targeting therapies in cancer have yet to make it to the clinic. New review published today in Nature Cancer by @ubellackerlab.bsky.social and Scott Dixon of Stanford share hurdles and ideas for future strategies to bring these therapies closer to the clinic. Check it out
rdcu.be/eBbqV
American Association for Cancer Research (AACR)
rdcu.be
Nature Cancer - Ubellacker and Dixon summarize the latest discoveries on ferroptosis in cancer, covering the molecular and cellular pathways underlying sensitivity and resistance to this type of...
Excited to share our work @nature.com! Postdoc @mariopalma.bsky.social, with major contributions from @retickerflynn.bsky.social and collaborators, discovered melanoma cells in lymph nodes gain a targetable FSP1 dependency that limits progression. #TeamFSP1
www.nature.com/articles/s41...
Nature Communications - Cytokines are immune signaling molecules that are frequently dysregulated in disease. Here, the authors create engineered cytokine ‘adaptors,’ molecular switches...
