A deep learning method quantitatively decodes nucleolar, nuclear speckle, and viral condensate morphology to reveal underlying biochemical states. Applying this framework reveals a previously…
Enhancer RNAs (eRNAs) are short, unstable RNA polymerase II transcripts from active enhancers processed by the Integrator complex. Once considered noncoding, recent work from Vlasov et al. shows that…
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ATG8 conjugation on damaged lysosomes triggers rapid assembly of a protein complex containing TFG, which directs lysosomal membrane repair by recruiting ESCRT proteins to sites of damage.
Valdivieso, Rozmaric et al. show that wounding rapidly induces a senescent state in skin cells involving p21 protein induction, without the need for new transcription. These senescent cells are…
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Mitochondria interact directly with the nuclear pore complex via VDAC1–RANBP2 binding to sustain nuclear ATP levels.
Ruptoblasts are a cytotoxic glandular cell type that undergoes explosive cell death, ruptosis, releasing potent, broad-spectrum agents capable of killing nearby cells. Ruptosis is triggered by the…
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Highly conserved mRNA 3′ UTRs act as co-translational chaperones for intrinsically disordered regions (IDRs), preventing inter-domain misfolding and enabling biogenesis of fully active proteins.
Nuclear and cytoplasmic proteomics uncover a nuclear pool of cytoskeletal proteins, including MAP1B, whose shuttling to the nucleus increases BRG1/BAF chromatin association and regulates brain…
The subcellular localization patterns of RNAs are controlled by regulatory elements contained within them. However, for most localized RNAs, the identities of these elements remain unknown. We had…
