The cartwheel was first visualized ~70 years ago in the symbiont Trichonympha in the wood termite gut. We’ve discovered the cartwheel’s secret: a unique zigzag stacking of SAS-6 tetramers that facilitates the iconic 9-fold symmetry of cilia.
#cellbiology #teamtomo #SAS6 #cartwheel
Oops, I forgot the preprint link
www.biorxiv.org/content/10.6...
Video
Cilia alert! Stoked to have the new paper from Juyeon Hong about a new domain at the extreme distal tip of motile cilia! (The EDT, y'all!) It's out now @natcomms.nature.com.
Check it out!
#cilia
www.nature.com/articles/s41...
Very happy to say that our work on how axonemes are generated is now available on bioRxiv: www.biorxiv.org/content/10.6... - if you’ve ever wondered how the incredibly beautiful, complex structures within motile #cilia are constructed then this is for you!
Excited to share our paper about copick, a dataset API and toolkit for collaborative annotation and analysis of #cryoET data! Whether you're picking particles or curating segmentations, copick reduces friction and brings #OME-Zarr to cryoET without breaking pipelines.
🧵👇
doi.org/10.1002/pro.70578
The printing profile & the Stl file can be downloaded here:
makerworld.com/en/models/24...
You need an AMS to print with color or just a single black for everything.
3D printing is way too much fun 😄
Just made myself a Titan Krios G5 pen holder 🧊🔬
Now the only thing missing… is McGill getting the real one! 😉
Check out @lee in action, harvesting hindguts from termites! 🐜🔬. Massive credit for pionering work from @centriolelab.bsky.social and others for establishing the isolation of centriole from Trichonympha and earlier model for central hub. We significantly benefit from advances in cryo-ET & STA.
I also started a MakerWorld page to share these files! There are only a few for now, but I’ll be uploading more as I go further down the 3D printing rabbit hole. 🕳️🐇
Grab the models here: makerworld.com/en/@user_763...
Video
Ever wanted to hold a cilium in your hand? 🧬✨
Here is a look at how I’m using CiliaBuilder in @UCSFChimeraX to generate accurate 3D prints of centrioles and cilia. Perfect for teaching or lab displays!
Watch the process: youtu.be/IKnnp3ovptQ #CryoEM #CellBio #ChimeraX
