Very happy to share this preview article written by my postdoc Danny on exciting recent work from @ostermanilya.bsky.social and @soreklab.bsky.social. New bacterial immunity, phage countermeasures, and a double pun combo in the title.
Jack Bravo
NAD to the bone: How bacteria put phages under aRES-t … and how phages fight back
Preview of work IDing aRES, bacterial proteins that deplete cellular NAD+, generating products that cannot be utilized by phage NAD+ regeneration pathways
www.cell.com/cell-host-mi...
www.cell.com
In this issue of Cell Host & Microbe, Osterman et al. discover aRES, a new family
of bacterial immune proteins that deplete cellular NAD+, generating cleavage products
that cannot be utilized by canon...
