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Assistant Professor @ ISTA Using cryo-EM to understand how bacteria defend themselves https://bravo-lab.org/
Jack Bravo
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Happy to share our latest pre-print on the Druantia defense system. We find that Type III Druantia uses a cooperative helicase-nuclease mechanism to sense and degrade replication-associated forked DNA structures. www.biorxiv.org/content/10.6... A🧵
The antiphage mechanism of a widespread trypsin-MBL defense module pubmed.ncbi.nlm.nih.gov/42243536/ #cryoEM
Really looking forward to sharing new (unpublished) work from our lab at this upcoming meeting!
1mo
www.nature.com/articles/s41...
Very happy to share this preview article written by my postdoc Danny on exciting recent work from @ostermanilya.bsky.social and @soreklab.bsky.social. New bacterial immunity, phage countermeasures, and a double pun combo in the title.
9d
Phage-encoded single-guide RNAs subvert CRISPR-Cas9 immunity https://www.biorxiv.org/content/10.64898/2026.06.01.729453v1
17d
Ancient wars between microbes gave us key immune defenses | @science.org | AAAS www.science.org/content/arti... #microsky #virosky #immunosky