CapK is a bacterial DNA damage-activated kinase that phosphorylates transcriptional repressor CapS to control adjacently-encoded anti-phage immune pathway genes in response to a universal stress signal, DNA damage
@kevincorbett.bsky.social and colleagues
link.springer.com/article/10.1...
Bacteria encode numerous stress-response pathways that protect their hosts against both internal and external threats. A key question is how these pathways are regulated, especially anti-phage immune ...
New preprint alert!!! 🚀🤓 We are very happy to finally share this with the world — the result of seven years of work and a new tool to study integrons and discover new functions encoded in these bacterial platforms.
If you want to know more, here is a thread 🧵
www.biorxiv.org/content/10.6...
The final version of our latest paper is now published in @natcomms.nature.com!
This study illustrates how #AntibioticResistance mechanisms can reshape bacterial physiology beyond resistance itself, ultimately influencing infection dynamics in clinically relevant ways🦠
www.nature.com/articles/s41...
A really cool method we are just starting to explore!
New preprint on the limits of detecting higher-order interactions in microbial communities.
www.biorxiv.org/content/10.6...
We find that the dominance of additive and pairwise interactions on community function may not reflect biological simplicity, but fundamental limits of statistical detection.
The EMBO Journal
Great work led by MBAlab @jaescudero.bsky.social with the invaluable collaboration of @sanmillan.bsky.social @baerboletta.bsky.social @penamiller.bsky.social and @ayari.bsky.social
Final version of our last paper is out!
www.nature.com/articles/s41...
