How do epithelial cells integrate mechanical and biochemical signals to control their behavior?
I am @ronjahoutekamer.bsky.social, and in this thread, I’ll show you how force transduction connects to biochemical signaling, and how it activates ERK by inducing biochemical ligand shedding.
The Bastounis Lab is at #CellMech2025 in Leuven 🇧🇪!
We explore how mechanics shape infection: from epithelial entry to endothelial barriers.
📅 Sept 30: Raúl Aparicio Yuste & Lara Hundsdorfer
📅 Oct 1:Julio César Sánchez Rendón, Marie Münkel, Nadine Oder& I
Excited for inspiring discussions! 🚀
We’re hiring! A PhD position (E13 TV-L, 65%) is available at @cmfi.bsky.social @unituebingen.bsky.social. The DFG-funded project explores how mechanical forces shape intracellular bacterial infections, focusing on Listeria. Details & application: www.euraxess.de/jobs/366585. Start: ASAP!
Synthetic materials accumulate damage with every mechanical challenge. Epithelial tissues are regularly loaded, yet healthy epithelia rarely rupture. Why?
We are @epmech.bsky.social and @baldaufsci.bsky.social and in this thread we introduce you to cyclic loading.
bsky.app/profile/epim...
Bastounis lab had a great time at @cellmech2025.bsky.social — such an engaging and well-organized #Mechanobiology conference in Leuven 🙌 Thanks to everyone for the inspiring exchanges! And big congrats to our lab member @hundsdorfer.bsky.social for winning the Best PhD Student Poster Prize 🎉
I'm excited to share our paper on how infected #macrophages promote #biomechanical alterations in #endothelia to transmigrate, published in @cp-cellreports.bsky.social! Thanks to all contributors, @sergemostowylab.bsky.social and @cmfi.bsky.social for the support. Here: www.cell.com/cell-reports...
Keshavanarayana, P., Aparicio-Yuste, R., Spill, F., Gomez-Benito, M. J., & Bastounis, E. E. (2025). Leveraging computational modeling to explore epithelial and endothelial cell monolayer mechanobiology. Trends in Cell Biology. #EpithelialMechanicsReview doi.org/10.1016/j.tc...
Listeria-infected macrophages promote biomechanical alterations in endothelial cell monolayers for transmigration