Keshavanarayana, P., Aparicio-Yuste, R., Spill, F., Gomez-Benito, M. J., & Bastounis, E. E. (2025). Leveraging computational modeling to explore epithelial and endothelial cell monolayer mechanobiology. Trends in Cell Biology. #EpithelialMechanicsReview doi.org/10.1016/j.tc...
epithelial mechanics fan club
How do epithelial cells integrate mechanical and biochemical signals to control their behavior?
I am @ronjahoutekamer.bsky.social, and in this thread, I’ll show you how force transduction connects to biochemical signaling, and how it activates ERK by inducing biochemical ligand shedding.
Synthetic materials accumulate damage with every mechanical challenge. Epithelial tissues are regularly loaded, yet healthy epithelia rarely rupture. Why?
We are @epmech.bsky.social and @baldaufsci.bsky.social and in this thread we introduce you to cyclic loading.
bsky.app/profile/epim...
epithelial mechanics fan club
epithelial mechanics fan club
Bastounis lab had a great time at @cellmech2025.bsky.social — such an engaging and well-organized #Mechanobiology conference in Leuven 🙌 Thanks to everyone for the inspiring exchanges! And big congrats to our lab member @hundsdorfer.bsky.social for winning the Best PhD Student Poster Prize 🎉
We hope you'll join us in Ascona, Switzerland for the upcoming thematic meeting Mechanobiology of Infection, June 7-11, 2026. Abstract submission and registration are now open! www.biophysics.org/meetings-eve...
Erva Keskin
Listeria-infected macrophages promote biomechanical alterations in endothelial cell monolayers for transmigration
Intracellular pathogens like Listeria exploit macrophages to cross endothelial barriers and spread systemically. Muenkel et al. show that exposure to infected macrophages weakens contractile forces within the endothelial monolayer and promotes macrophage transmigration. This response is driven by direct cell-cell interactions, with cytokines exerting only minor and transient effects.
Looking for a method to characterise cell #motility and #ERK signalling waves?
Check out our STAR protocols paper:
star-protocols.cell.com/protocols/41...
Thanks for the great work Julio Cesar Sanchez-Rendon & @effiebastounis.bsky.social!
#protocol #epithelia #FRET #singlecell #imaging
I'm excited to share our paper on how infected #macrophages promote #biomechanical alterations in #endothelia to transmigrate, published in @cp-cellreports.bsky.social! Thanks to all contributors, @sergemostowylab.bsky.social and @cmfi.bsky.social for the support. Here: www.cell.com/cell-reports...
Intracellular pathogens like Listeria exploit macrophages to cross endothelial barriers
and spread systemically. Muenkel et al. show that exposure to infected macrophages
weakens contractile forces wi...
We’re hiring! A PhD position (E13 TV-L, 65%) is available at @cmfi.bsky.social @unituebingen.bsky.social. The DFG-funded project explores how mechanical forces shape intracellular bacterial infections, focusing on Listeria. Details & application: www.euraxess.de/jobs/366585. Start: ASAP!
