Precise bacterial genome editing has been largely stuck in E. coli. Scientists at @gladstoneinst.bsky.social just changed that, showing that their retron-based editing tools work across 15 diverse species of bacteria. gladstone.org/news/univers...
A microscope at @gladstoneinst.bsky.social is on the search for new Parkinson's treatments. It designs its own experiments, runs thousands simultaneously on individual cells, learns from the results, and repeats-- without guidance from scientists. gladstone.org/news/how-ai-...
Sarah CP Williams
Sarah CP Williams
For the first time, a vaccine reliably produced broadly neutralizing HIV antibodies in every animal tested. @scripps.edu & @ki.se researchers targeted the apex of HIV's spike, a region nearly identical across hundreds of thousands of strains. www.scripps.edu/news-and-eve...
How does the brain drain its waste? A new method developed at @gladstoneinst.bsky.social maps the routes proteins takes out of the brain. The result: unexpected biology, and new insight into how disease disrupts the brain's cleanup system. gladstone.org/news/mapping...
Brain immune cells stay chronically overactivated in Alzheimer's, destroying synapses. @scripps.edu scientists traced that inflammation to a single chemical modification on one protein. Blocking the modification protects synapses in mice. www.scripps.edu/news-and-eve...
Scientists thought DNA wrapped in nucleosomes was either locked away or accessible, on or off. "It's more like a volume dial," says @gladstoneinst.bsky.social's Vijay Ramani. An AI tool described in @nature.com found 14 nucleosome states- a new layer of genomic grammar. gladstone.org/index.php/ne...
Ventricular fibrillation moves so fast that sending cardiac data to a remote server takes too long to save a life. A new skin-like AI computing patch from @SihongWang_UChi @UChicagoPME runs the analysis in milliseconds, directly on the body. pme.uchicago.edu/news/researc...
Carbon capture and CO₂ conversion are usually two separate, expensive steps. @uchicagopme.bsky.social and Argonne scientists combined them into one system that works efficiently even under messy, real-world flue conditions. pme.uchicago.edu/news/researc...
Scientists at Gladstone expanded their retron-based genome editing technology beyond E. coli, showing it works in 15 diverse bacterial species.
gladstone.org
ChatGPT learned language from millions of texts. @gladstoneinst.bsky.social's Geneformer learned the language of human genes from 100 million cells. Now, it can predict which genes to target to fix diseased cells. My latest for a Gladstone series on science & AI: gladstone.org/news/how-ai-...
At @columbiamed.bsky.social, scientists are no longer betting everything on a single, simple explanation for Alzheimer's. Instead, they are mapping the subtypes, the way oncologists once did for cancer, to finally develop targeted treatments. www.vagelos.columbia.edu/about-us/col...
Gladstone scientists have developed a thinking microscope that can conduct its own experiments, with the ultimate goal of treating neurodegenerative diseases.
A new study upends long-held view about how DNA is stored, explaining how subtle shifts in gene activity contribute to cancer, aging, and other complex diseases.
Gladstone scientists are developing novel AI models to predict what goes wrong in disease—and how to fix it.
gladstone.org
Approaching Alzheimer’s from every angle, Columbia scientists are finding unexpected inroads to this complex disease and forging paths to new treatment possibilities.
A new fabrication method enables large-scale stretchable transistor arrays to run AI algorithms directly on the body, without transmitting data to an external computer
pme.uchicago.edu
The new approach, developed by UChicago PME and Argonne National Laboratory researchers, offers a streamlined and cost-effective pathway toward decarbonization.
