Scientists thought DNA wrapped in nucleosomes was either locked away or accessible, on or off. "It's more like a volume dial," says @gladstoneinst.bsky.social's Vijay Ramani. An AI tool described in @nature.com found 14 nucleosome states- a new layer of genomic grammar. gladstone.org/index.php/ne...
A new study upends long-held view about how DNA is stored, explaining how subtle shifts in gene activity contribute to cancer, aging, and other complex diseases.
