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Nature Cancer
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⭐️Online now
Iron level and ferroptosis impair antitumor efficacy of CAR-T cells.
by Dongrui Wang, Yongxian Hu, Pengxu Qian, He Huang & colleagues
www.nature.com/articles/s43...
🍓☀️Check out our May Issue, now live!
Including:
☑️Oncolytic virus and cytokine-based gene therapies
☑️Myeloid plasticity, part of our Series on Tumor Heterogeneity and Plasticity
☑️DeepFAN, a model for human-AI collaboration
and more!
www.nature.com/natcancer/vo...
⭐️Check out the Perspective on cellular neighborhoods in cancer by Lichun Ma, @kaitanlab.bsky.social & co
🔗 www.nature.com/articles/s43...
Part of our Series on Tumor Heterogeneity and Plasticity:
www.nature.com/collections/...
New Article out today!
CD300ld, upregulated in pathologically activated neutrophils, mediates contact-dependent suppression of cytotoxic CD8+ T cells by binding to phosphatidylserine, inhibiting antitumor immune responses and revealing a targetable checkpoint pathway.
www.nature.com/articles/s43...
🌟 Online now!
Read the Review on myeloid cell plasticity in cancer therapy by Dmitry Gabrilovich & colleagues
🔗 www.nature.com/articles/s43...
Check out the rest of our Series on Tumor Heterogeneity and Plasticity here: www.nature.com/collections/...
⭐Out today!
Read the phase I clinical trial on neoantigen DNA vaccine for patients with glioblastoma
www.nature.com/articles/s43...
📢Online now!
@moritzgerstung.bsky.social, Felix Sahm & co developed an AI algorithm that leverages H&E slides to classify central nervous system tumors into methylation-based subtypes reducing turnaround time to 12 min in prospective evaluation.
www.nature.com/articles/s43...
⭐️Now online
In a large cohort of patients with ICB-treated glioblastoma, Catherine J. Wu & colleagues show that baseline mesenchymal transcriptional state predicts therapy response, and transition to non-mesenchymal state results in acquired resistance.
www.nature.com/articles/s43...
Registration and abstract submissions are now open for Next Generation Cancer Therapeutics. This Nature Conference will bring together leading global researchers who are transforming the landscape of cancer therapies for discussions and networking. go.nature.com/4eHSlnc #STEMConference
Impressive new study by the Wu lab in @natcancer.nature.com investigating the tumor cell features associated with #immunotherapy response in #glioblastoma
Tumor transcriptional state predicts survival in immune-checkpoint-blockade-treated glioblastoma | Nature Cancer
www.nature.com/articles/s43...
Huang and colleagues report that elevated iron levels are associated with ferroptosis of chimeric antigen receptor (CAR)-T cells and inhibition of ferroptosis improves antitumor efficacy of CAR-T cell...
www.nature.com
Tan and colleagues discuss recent advances in spatial omics and computational models that inform the classification and clinical relevance of cellular neighborhoods in cancer.
Zhao and colleagues show that CD300ld, upregulated in pathologically activated neutrophils, mediates contact-dependent suppression of cytotoxic CD8+ T cells by binding to phosphatidylserine, inhibitin...
Gabrilovich and colleagues provide an overview of myeloid cell plasticity during differentiation, within the tumor microenvironment and in response to therapy, and discuss the challenges to therapeuti...
Johanns and colleagues report the results (including safety, efficacy and immunogenicity) of a phase 1 clinical trial of a DNA-based personalized therapeutic cancer vaccine administered following surg...
Jin et al. developed an artificial intelligence tool that leverages histology to predict methylation-based central nervous system tumor subtypes and validated it for tumor classification, demonstratin...
In a large cohort of participants with immune-checkpoint-blockade-treated glioblastoma, Ghannam et al. show that baseline mesenchymal transcriptional state predicts therapy response and transition to ...
In a large cohort of participants with immune-checkpoint-blockade-treated glioblastoma, Ghannam et al. show that baseline mesenchymal transcriptional state predicts therapy response and transition to ...
