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Iron level and ferroptosis impair antitumor efficacy of CAR-T cells.
by Dongrui Wang, Yongxian Hu, Pengxu Qian, He Huang & colleagues
www.nature.com/articles/s43...
www.nature.com
Huang and colleagues report that elevated iron levels are associated with ferroptosis of chimeric antigen receptor (CAR)-T cells and inhibition of ferroptosis improves antitumor efficacy of CAR-T cell...