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Immunologist, NHMRC Fellow & Lab Head, Integrated Mucosal Immunity Lab @MonashUni
Cyril Seillet, PhD









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Interesting approach from Chao Zhong’s group to dissect the role of RORgt in activated ILC3 highlighting its essential function in driving HB-EGF expression, rather than IL-22. www.cell.com/cell-reports...
🎓 PhD positions available @MonashUni Join our lab to explore how neurons and immune cells shape gut immunity! 🧬 Single-cell RNAseq 🔬 3D imaging 🧠 Neuro-immune interactions 👥 Great mentoring & collaborations Apply now 👉 tinyurl.com/Seilletlab
🧠🍔 Just 48 hours on a high-fat diet can weaken gut immunity. Our new study shows saturated fats rapidly impair ILC3s! Proud to see this featured by @wehi-research.bsky.social as I continue to explore these questions @monashuniversity.bsky.social with the IMI Lab!
Jun 6, 2025
Jun 2, 2025
We're looking for a post-doc to join our team @wehi-research.bsky.social The project is fast paced and challenging, but its going to be a ton of fun! Apply now and please spread the word wehi.wd3.myworkdayjobs.com/broadbean_ex....
Thrilled to share our latest review on how the gut microbiome connects diet to health, now published in Nature Reviews Gastro & Hepa! Honored to co-sign this piece with outstanding PIs @eranelinav.bsky.social @jfcryan.bsky.social Yolanda Sanz Mélanie Deschasaux Rebekka Lambrecht rdcu.be/epret
May 19, 2025
A landmark WEHI-led study has uncovered how our daily food choices are having an immediate effect on our gut health. Brilliant research led byDr Cyril Seillet and Dr Le Xiong, that could help pinpoint #chronicinflammation at the source. Now published in Immunity. www.wehi.edu.au/news/fast-fo...
Thrilled to share our work now published on @cp-immunity.bsky.social . Big thanks to our collaborators. Here we show that short-term High-Fat diet impairs ILC3 functions in producing IL-22 through microbiota-dependent and-independent mechanisms.
Not one, not two .... but FIVE recent papers highlighting a role for RORgt+ antigen-presenting cells in the gut in establishing tolerance to food antigens #oraltolerance #immunosky #foodallergy
Jun 6, 2025
Jun 4, 2025
tinyurl.com
May 19, 2025
Apr 15, 2025
Understanding the neuroimmune regulation of innate immunity | Supervisor Connect
Excited to have our latest research published in @jem.org this week and also highlighted by @natrevimmunol.nature.com @wehi-research.bsky.social @benjbroom.bsky.social
Excited to see our work published on @cp-immunity.bsky.social. Also shared by a nice commentary. really like the last sentence: “Not all fuel nourishes; some, once ignited, may burn beyond control.”
May 29, 2025
Cyril Seillet, PhD
Cyril Seillet, PhD
Cyril Seillet, PhD
May 18, 2025
May 8, 2025
Putoczki Lab
Patrick Veiga
Le Xiong
WEHI (The Walter and Eliza Hall Institute of Medical Research)
Le Xiong
Nature Reviews Immunology
Joanna Groom
A landmark WEHI-led study has uncovered how our daily food choices are having an immediate effect on our gut health. Brilliant research led byDr Cyril Seillet and Dr Le Xiong, that could help pinpoint #chronicinflammation at the source. Now published in Immunity. www.wehi.edu.au/news/fast-fo...
May 19, 2025
www.cell.com
Li et al. show that RORγt, the ILC3 master regulator, still plays a crucial role during the ILC3 activation phase. Although it is dispensable for ILC3 maintenance and their IL-22 production, it is req...
RORγt is crucial for gut homeostasis by regulating the expression of HB-EGF rather than IL-22 in activated ILC3s
WEHI (The Walter and Eliza Hall Institute of Medical Research)
Five recent papers identify the RORγt+ antigen-presenting cells that induce food-antigen-specific regulatory T cells and establish food tolerance.
www.nature.com
RORγt+ antigen-presenting cells mediate food tolerance - Nature Reviews Immunology
www.nature.com
A study shows that transient blockade of type I interferon signalling during T cell priming enhances the generation of stem cell-like memory CD8+ T cells after viral infection and mRNA vaccination.
Brief blockade of type I IFN increases CD8+ T cell memory - Nature Reviews Immunology
Future vaccines a step closer. Research from @groomlab.bsky.social, @benjbroom.bsky.social and team use novel approach and mRNA tech to boost stem cell-like memory CD8+ T cells after vaccination. Published in @jem.org www.wehi.edu.au/news/vaccine...
May 7, 2025
Job Title Senior Research Officer Job Description An exciting opportunity exists for a talented and commercially focused researcher with a strong interest in immunology to join the Putoczki Laboratory...
wehi.wd3.myworkdayjobs.com
Senior Research Officer
Nature Reviews Gastroenterology & Hepatology - In this Review, Sanz and colleagues discuss how diet shapes the gut microbiome, the role of diet–microbiome interactions on the immune,...
rdcu.be
The gut microbiome connects nutrition and human health