🚨 New preprint: GATO-seq did it again! ELOF1 is the missing promoter-proximal factor that confers RNA Pol II resistance to TFIIF. Including ELOF1, DSIF, and NELF in GATO-seq reactions recapitulates promoter-proximal pausing in vitro at physiological conditions for the 1st time.
tinyurl.com/ELOF1
Video
Roberto Vázquez Núñez
Notice of Temporary Extension of Eligibility for the NIH Pathway to Independence Award (K99/R00):
for Individuals whose final due date was September-November 2025 and January-March 2026. As always, reach out to your PO/IC contact to discuss.
grants.nih.gov/grants/guide...
Excited to share our latest work from first author Patrick Woida. Using a novel surface display platform for expression of split TurboID, we discovered that CYLD is recruited to the Listeria surface via the effector InlC and that it supports cell-to-cell spread www.biorxiv.org/content/10.6...
Check out our latest paper from first author Allison Scott using a powerful enrichment strategy to enable transcriptional profiling of the early stages of a rickettsial infection
Interested in genetically encodable inhibitors of your favorite biomolecular condensate? Excited to announce our latest work, w/ Jibin Sadasivan, Gene-Wei Li, & Lindsay Case, on protein fragments as generalizable regulators of phase separation. (1/n)
www.biorxiv.org/content/10.6...
How every layer of science's "self-correcting machinery" failed when Iva Veseli and I simply wanted to reproduce the findings of a high-profile study on gut microbiome and autism:
merenlab.org/2026/04/15/u...
With CauloCon coming up in a few weeks, we are excited to share with you the schedule for the upcoming meeting! There will be 3 keynotes and 26 short talks over three days.
You can see more information at caulocon.com
Our most recent paper "Divergent Rickettsia species exhibit distinct mechanisms of actin-based motility" is now out in @jcb.org! Check it out here: rupress.org/jcb/article/...
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Notice of Temporary Extension of Eligibility for the NIH Pathway to Independence Award (K99/R00) NOT-OD-26-021. OD
I'm happy to share a review that our lab put together on innate immune responses to Rickettsia. One interesting tidbit - different Rickettsia species have distinct interactions with xenophagy, where some species co-opt ubiquitylation, while others avoid it!
www.sciencedirect.com/science/arti...
The myth of open data, reproducibility, responsibility, and accountability in science, and your role in it
Over 10 species of Rickettsia cause serious human disease across the globe, including deadly spotted fever and typhus. These arthropod-borne microbes …
