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🚨 New preprint: GATO-seq did it again! ELOF1 is the missing promoter-proximal factor that confers RNA Pol II resistance to TFIIF. Including ELOF1, DSIF, and NELF in GATO-seq reactions recapitulates promoter-proximal pausing in vitro at physiological conditions for the 1st time. tinyurl.com/ELOF1
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Glad to have presented my postdoctoral work from the @voslab.org lab in the last machines on genes conference. Thank you to the organizers and to the @biochemsoc.bsky.social for the opportunity and for bringing us to beautiful Crete. #Biochemevents
Targeted degradation of ELOF1 in human cells results in shorter residence time of RNA Pol II at promoter-proximal regions. Thank you to our great collaborators from the Mayer lab: Annkatrin Bressin and Derek Shao.