Chief Editor for Biotechnology at Nature Communications. This is gonna be mostly science, sometimes other stuff. All views my own. he/him
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Spatially blocked split CRISPR-Cas12a system for ultra-sensitive and versatile small molecule activation and detection
www.nature.com/articles/s41...
Detecting small molecules is pivotal across many fields. Here, authors leverage a split crRNA mode to construct spatially blocked split CRISPR-Cas12a system. This approach establishes a low-background...
Circular RNA-mediated inverse prime editing in human cells
www.nature.com/articles/s41...
Sucrose-driven carbon redox rebalancing eliminates the Crabtree effect and boosts energy metabolism in yeast
www.nature.com/articles/s41...
Prime editor with rational design and AI-driven optimization for reverse editing window and enhanced fidelity
www.nature.com/articles/s41...
Precision multiplexed base editing in human cells using Cas12a-derived base editors
www.nature.com/articles/s41...
Prime editors are restricted to performing precise edits downstream of cleavage sites. Here, authors develop helicase-assisted circular RNA-mediated inverse PEs (ciPEs) to increase editing efficiencie...
The Crabtree effect affects yeast-based bioproduction. Here, the authors report the development of a Crabtree-negative yeast through introducing the sucrose phosphorolysis pathway, deletion of the pho...
Expanding editing scope while reducing byproducts is now possible for prime editing. Here, authors develop reverse prime editing (rPE), a SpCas9-based tool enabling editing in reverse window with high...
www.nature.com
Current base editors cannot simultaneously edit multiple loci with base-pair level precision, hindering complex genotype generation. Here the authors describe optimized Cas12a gRNA array designs, enab...
