Happy to announce the publication of our work exploring under-appreciated genetic diversity in the human IGHC region. Awesome work by @uddalok.bsky.social. So grateful for our amazing co-authors.
@williamlees.bsky.social @guryaari.bsky.social @ayeletperes.bsky.social
www.cell.com/cell-genomic...
🧬 VDJbase and OGRDB: 3000+ IG/TR samples across human and rhesus macaque with curated AIRR-seq and long-read genomic data.
LET'S CHANGE THE WAY WE UTILIZE IG/TR GENOMIC AND REPERTOIRE DATA! @guryaari.bsky.social @williamlees.bsky.social @ayeletperes.bsky.social
academic.oup.com/nar/advance-...
If you thought human IG was complicated, ruminant IG wants to change your mind! Awesome overview of the ruminant IG genomic landscape by Yana Safonova (Penn State) www.annualreviews.org/content/jour...
www.cell.com
academic.oup.com
Abstract. Accurate characterization of adaptive immune receptor repertoires through high-throughput sequencing is critical for understanding immune respons
Genetic variation within immunoglobulin heavy chain constant (IGHC) genes modulates
interactions between antibodies and other immune receptors and effector cells, directing
cell killing and the cleara...
Ruminant species are vital for agriculture, ecosystems, and conservation and remain vulnerable to infectious and zoonotic diseases. Advances in genome sequencing and genomics now enable high-resolutio...
LifeSciKY has welcomed three biotech startups to the new OneNKY Center in Covington. Learn more about the companies and their work in cancer research, immune profiling, and fertility innovation.
linknky.com/business/ent...
LifeSciKY’s new lab at the OneNKY Center in Covington welcomed three biotech startups focused on cancer therapy, genomics and fertility.
New manuscript out in NAR! tinyurl.com/4rrbuesn
🧬 VDJbase and OGRDB now support 3000+ IG/TR samples across human and rhesus macaque with curated AIRR-seq and long-read genomic data. From population analysis to precision annotation. @guryaari.bsky.social @cdubsig.bsky.social @williamlees.bsky.social
Query by ancestry, tissue, chain, or study.
Explore allele usage, haplotypes, and gene presence/absence with interactive tools.
Download via API or browser.
Fully FAIR, MiAIRR-compliant, open, and versioned.
vdjbase.org
#AIRR #Immunogenetics
Excited to see our work on IGHC diversity out! Huge shoutout to @uddalok.bsky.social for leading this study.
🧬 The data is now available on VDJbase, our open resource for exploring B and T cell germline variation across populations. 🧑🔬 Go and Explore vdjbase.org!
#immunogenetics #VDJbase
academic.oup.com
vdjbase.org
Abstract. Accurate characterization of adaptive immune receptor repertoires through high-throughput sequencing is critical for understanding immune respons
Happy to announce the publication of our work exploring under-appreciated genetic diversity in the human IGHC region. Awesome work by @uddalok.bsky.social. So grateful for our amazing co-authors.
@williamlees.bsky.social @guryaari.bsky.social @ayeletperes.bsky.social
www.cell.com/cell-genomic...
Happy to see this work on IG light chains from @e-engelbrecht1.bsky.social in press www.nature.com/articles/s41...
How else will germline variation impact the expressed repertoire? Can't wait to see!
Thanks to awesome collabs:
@williamlees.bsky.social @guryaari.bsky.social @ayeletperes.bsky.social
Very happy to see this new and improved IG genetic resource for Rhesus Macaque published today in Immunity! An enjoyable and fruitful collaboration with Steve Bosinger & team (Emory), @guryaari.bsky.social, @ayeletperes.bsky.social and @williamlees.bsky.social - More to come!
doi.org/10.1016/j.im...
Genetic variation within immunoglobulin heavy chain constant (IGHC) genes modulates
interactions between antibodies and other immune receptors and effector cells, directing
cell killing and the cleara...
Antibody response variability contributes to differential individual responses and disease outcomes. Here authors show that genetic variation to the IG kappa and IG lambda loci is an important determi...
'The mechanisms controlling the inclusion of new B cell clones into spontaneous germinal centers (GCs) remain unclear. Using CRISPR-Cas9, we generated 2 autoreactive B cell receptor knock-in strains, M05 and G55, based on B cell receptors from WT GC B cells in WT:564Igi chimeras'
Abstract. Systemic lupus erythematosus is characterized by activation of many self-reactive B cell clones that produce autoantibodies. This can be modeled
