➡️ What drives the anticancer activity of plecstatin in hepatocellular carcinoma?
📖 Researchers from the gregorlab.bsky.social at @imgprague.bsky.social identify plectin as key target of this metallodrug, dissecting its anti-tumor activity.
🔓 Full text: febs.onlinelibrary.wiley.com/doi/full/10....
Our latest issue is out! 📣
🔍 We are pleased to present manuscripts showcasing a breadth of topics from insights into tumour evolution, new approaches to intercept cancer before it develops, and novel therapeutic targets in glioblastoma.
🔓 Full issue: febs.onlinelibrary.wiley.com/toc/18780261...
🔬 Curious about mechanisms driving melanoma progression and metastasis?
The Wolnicka-Głubisz lab identified RIPK4 as a regulator of melanoma cell adhesion and metastasis, highlighting its role as a modulator of tumour plasticity. 👏
🔓 Full text: febs.onlinelibrary.wiley.com/doi/10.1002/...
We’re thrilled to reveal the winners of the Molecular Oncology Writing Contest 2026! 🎉
🏆 Muhammad Habiburrahman
🥈 Alyssa Paparella
🥉 Ihsaan Jama
➡️ Read their essays on: febs.onlinelibrary.wiley.com/hub/journal/...
👏 Congratulations! Way to go!
#SciComm #FEBS #WritingCommunity #OpenAccess
🔬 Researchers from the Jan Hahn group combined NIRL laser tissue sampling with lipidomics to identify lipid signatures to distinguish oropharyngeal squamous cell carcinoma from adjacent healthy tissue, supporting rapid molecular diagnostics.
Full text: febs.onlinelibrary.wiley.com/doi/10.1002/...
💡 Can cancer be stopped before it starts?
In a Viewpoint, researchers from the
@charlesswanton.bsky.social
lab discuss cancer interception, to prevent cancer before it develops. Could this be the next frontier in oncology?
🔓 febs.onlinelibrary.wiley.com/doi/10.1002/...
#CancerPrevention #EACR
💡Interested in PD-L1 regulation in melanoma?
📖 A new study from the Annemiek van Spriel and colleagues identifies TSPAN4 as a negative regulator of PD-L1 in melanoma, uncovering a new layer of immune checkpoint regulation.
🔓 Read the full manuscript: febs.onlinelibrary.wiley.com/doi/10.1002/...
💡This week we highlight a study from the Jochen Utikal lab at @dkfz.bsky.social.
🧬Authors provide new insights into overcoming therapy resistance in melanoma, suggesting ERRFI1 as a potential target for treatment of metastatic melanoma.👏
➡️ Full text: febs.onlinelibrary.wiley.com/doi/10.1002/...
📖 Researchers from the Warsaw University review emerging evidence on large-conductance calcium-activated potassium (BKCa) channels and their role in glioblastoma biology, highlighting the translational challenges of developing BKCa-targeted therapies.
👉 febs.onlinelibrary.wiley.com/doi/10.1002/....
🔬 From the latest issue: The Keiner lab at the @uni-jena.de investigated the role of the chloride cotransporter NKCC1 in glioblastoma as a prognostic marker, suggesting that restoring chloride homeostasis may represent a promising therapeutic strategy.
🔓 febs.onlinelibrary.wiley.com/doi/10.1002/...
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD-L1 interactome of melanoma cells. TSPAN4 negatively regulates PD-L1 expression and lateral mobility by limit...
