💡Interested in PD-L1 regulation in melanoma?
📖 A new study from the Annemiek van Spriel and colleagues identifies TSPAN4 as a negative regulator of PD-L1 in melanoma, uncovering a new layer of immune checkpoint regulation.
🔓 Read the full manuscript: febs.onlinelibrary.wiley.com/doi/10.1002/...
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD-L1 interactome of melanoma cells. TSPAN4 negatively regulates PD-L1 expression and lateral mobility by limit...
