Post doc in the Ecker lab @ The Salk Institute. PhD in the Bailey-Serres lab @ UCR. Posts include papers I'm reading and things that I 3D print
@TrALEE_Sci on Twitter
Travis Lee
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Zooming in on these cells, GRN construction reveals bifurcating regulatory networks that asymmetrically drive cell elongation through hormonal regulation. As predicted by our GRN, we also rescue our mutant phenotype with exogenous GA hormone treatment 5/8
Lastly, I would like to thank all authors for their contributions, who have made all of this work possible! 8/8
We identify a transient cell niche below the shoot meristematic region that functions as a regulatory 'hub,' and find that mutation of TFs specifically expressed and with binding activity in these cells leads to defects in apical hook form 4/8
How do organisms grow an arch? In the apical hook, counter hormone gradients drive cell elongation asymmetrically; but as a standing wave cells transiently enter and exit the apical hook over a span of hours, which complicates our understanding of this structure 2/8
We also provide interactive access to at our web portal to explore expression data and TF motif activity within our single-cell and multi-modal datasets. 7/8
arabidopsisdevatlas.salk.edu
Using genetic mutants and manual dissection, we find vast heterogeneity within cell types in the apical hook attributed to intersecting developmental and hormonal regulation. Our spatial datasets enable the identification of the (developmental) time and place of this regulation 3/8
How do cells break symmetry to generate new shape and form? Using the apical hook as a model, we @joeecker.bsky.social applied spatial and single-cell multiomics, and identify a regulatory hotspot in a transient cell niche that drives this U-shaped structure 1/8
bsky.app/profile/bior...
This results in a model where positionally defined cell states bifurcate to asymmetrically regulate cell elongation to form the apical hook arch. We hypothesize that these divergent regulatory networks may be utilized broadly to regulate plant morphogenesis and bending 6/8
Travis Lee
Thrilled to share that our paper is now online in @PlantPhys 🌱 🍅
doi.org/10.1093/plph...
Many thanks to all co-authors and collaborators who made this work possible!!!
Also, thanks to Hannah Rae Thomas for summarizing our work here: doi.org/10.1093/plph...
