Happy to share our work on pancreatic ductal organoids from the human-relevant pig model across developmental stages ranging from embryonic to adult animals and using them for drug screening applications from the @heikolickert.bsky.social lab. #PancSky #devbio 🧪🧬 www.biorxiv.org/content/10.1... /1
Happy to share a new tool from the @heikolickert.bsky.social lab!
We generated human iPSC fluorescent reporter lines to monitor Wnt/PCP signaling activity by Flattop in stem cell derived β-cells.
doi.org/10.1016/j.sc...
Thanks to all the co-authors that helped in the present and the past!
Excited to see our review out in @cp-trendsendomet.bsky.social!
Great team effort and lots of fun to dive into how #islets form and how we can use this knowledge for #diabetes therapy.
@mireiamoli.bsky.social @ckarampelias.bsky.social @heikolickert.bsky.social
www.sciencedirect.com/science/arti...
Thrilled to share one of our biggest discoveries: “Inceptor binds to and directs insulin towards lysosomal degradation in beta cells”.
doi.org/10.1038/s422...
A tremendous collaborative effort led by JohannaSiehler, Sara Bilekova and other members of the Lickert lab @heikolickert.bsky.social
Join us in a beautiful location for this multidisciplinary experience. Top speakers linking topics such as organoid modeling, synthetic biology, gene regulation or genetics with disease mechanisms & new therapies for T1D, T2D, and MASLD
meetings.embo.org/event/25-liver-pancreas
Primary human pancreatic ductal organoids (HPDO) have emerged as a model to study pancreas biology and disease. Yet, donor material availability, and a lack of extensive benchmarking limits the range ...
Islets of Langerhans are highly structured mini-organs containing hormone-producing cells of the pancreas that regulate glucose metabolism. Studies of…
www.sciencedirect.com
The insulin inhibitory receptor (inceptor) is found to bind to insulin and to regulate insulin stores by directing proinsulin and insulin towards lysosomal degradation.
The liver and pancreas arise from a common developmental origin and are controlled by shared gene regulatory programs.These organs are central to two of the most common and devastating metabolic dise…
💥 Great fun writing this #review with @alejotorrescano.bsky.social
– reflecting on the emergence of #pancreatic #lineages in the #embryo through the lens of #plasticity -
Just out online ➡️ rdcu.be/fiw3c
@wellcometrust.bsky.social @kingscollegelondon.bsky.social @kingslsm.bsky.social
Tobias Greisle
My top highlight for 2025 - EMBO workshop in Saint Feliu - three exciting days of science crossing boundaries of liver & pancreas research! Co-organised by @CebolaLab @1jorgeferrer @VallierLab @LickertHeiko & Emma Anderson #livertwitter #islets #masld #diabetes
meetings.embo.org/event/25-liv...
Tobias Greisle
Jorge Ferrer
Heiko Lickert
Nature Reviews Gastroenterology & Hepatology - Pancreatic development is a dynamic process. This Review discusses the development and cellular plasticity that occurs in the pancreas in health...
The liver and pancreas arise from a common developmental origin and are controlled by shared gene regulatory programs.These organs are central to two of the most common and devastating metabolic dise…
