Exciting breakthrough technology from the lab, now live in
@cellcellpress.bsky.social
! Instead of cutting the genome where proteins bind (e.g., Cut&Tag), D&D-seq scars the DNA with a deaminase, allowing single cell genome mapping of TFs and chromatin remodellers!
I'm very excited to announce that my PhD work is out on biorxiv!
pyTrance is a computational method to predict and quantify subcellular RNA co-localization from spatial transcriptomics data.
www.biorxiv.org/content/10.6...
I'm very happy to say that my first first-author paper has been published in Bioinf. Advances! 1/2
academic.oup.com/bioinformati...
New paper! How do RNAs "know" where to go inside a cell? We dug into the sequence elements that route RNAs to the right place. It turns out that, in mammals, they're surprisingly massive (>200 nt), multipartite, and wonderfully complicated. 🧵
1\ Excited to finally share some of my PhD work: OpenSplice!
We measured how >590,000 mutations affect exon inclusion across 600 human exons, creating a resource to study splicing regulation, benchmark variant effect predictors, and support variant interpretation.